In a nutshell This study aimed to investigate the safety and effectiveness of zanubrutinib in patients with relapsed/unresponsive chronic lymphocytic leukemia and small lymphocytic lymphoma. This study concluded that zanubrutinib was well tolerated and with promising effectiveness in these patients. Some background Bruton tyrosine...
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In a nutshell The study analyzed multiple clinical trials for assessing the effects of carfilzomib (Kyprolis) based treatment on kidney toxicity in patients with multiple myeloma (MM). The main finding was that kidney toxicity was an important side effect of carfilzomib based therapy. Some background Carfilzomib is largely used to treat MM. It is a...
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In a nutshell The study evaluated occurrence, risk-factor, and exercise response of cardiac autonomic dysfunction (CAD) in adult survivors of childhood acute lymphoblastic leukemia (ALL). The authors found that over one-third of survivors developed CAD. It was related to lower exercise capacity. Some background Survivors of childhood ALL have reduced...
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In a nutshell This study looked at the outcomes of patients with type 2 diabetes (T2D) who were diagnosed with COVID-19. It found that patients with well-controlled blood glucose had fewer medical interventions and notably better survival. Some background COVID-19 is a highly infectious coronavirus that emerged in the Hubei province of China in late...
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In a nutshell This study investigated ocular (eye) conditions (OCs) in patients with rheumatoid arthritis (RA). They found that OCs affect approximately 20% of patients with RA. Some background Rheumatoid arthritis (RA) is a chronic immune condition. It is caused by painful inflammation in the joints. This leads to joint damage and disability...
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In a nutshell This study investigated the effectiveness of minimally invasive surgery in rectal cancer. Researchers suggested that less invasive surgery methods can result in better short-term outcomes in appropriately selected patients. Some background Colorectal cancer is the third most common cancer in the US. Rectal cancer comprises around 20% of...
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In a nutshell This study investigated the effects of malnutrition in elderly patients with Parkinson's disease (PD). Researchers suggested that patients with more advanced PD are more likely to be malnourished. Some background PD is a chronic disease that affects the brain cells. These cells lose their ability to control body functions which...
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In a nutshell This study reviewed the effect of diet on nocturia (waking up at night to urinate) severity. Some background Nocturia is among the most common and bothersome urinary symptoms. It increases with age and is associated with mortality due to its effects on sleep and daytime activity. It also increases the risk of falls and...
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In a nutshell This study investigated the effectiveness of the combined treatment with cytokine-induced killer cell (CIKC) immunotherapy and chemotherapy after surgery in colorectal cancer. Researchers suggested that this therapy improves treatment outcomes in patients with colorectal cancer. Some background Colorectal cancer is one of the most common...
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In a nutshell This study compared whether radiotherapy (RT) was more effective when combined with hormone therapy or brachytherapy (BT) for patients with localized prostate cancer (PC). The authors found that patients who received hormone therapy and RT survived for longer. Some background External beam radiotherapy (EBRT) focuses beams of...
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In a nutshell This study examined the effectiveness and safety of adding brentuximab vedotin (Adcetris) to R-CHP (rituximab, cyclophosphamide, doxorubicin, and prednisone) chemotherapy for patients with non-Hodgkin lymphoma (NHL). The authors concluded that the treatment was very effective and safe for patients. Some background Chemotherapy...
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In a nutshell This study investigated if fetal congenital malformations (FCM) are linked to recurrent miscarriage (RMC). They found that FCM was more likely in women with a history of RMC and birth defects. Some background Recurrent miscarriage (RMC) is defined by 2 or more failed pregnancies. RMC can be caused by a number of issues....
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