In a nutshell This study compared autologous stem cell transplant (SCT) to treatment with the proteasome inhibitor and chemotherapy regimen VMP (bortezomib, melphalan, prednisone) for patients with multiple myeloma (MM). It found that SCT led to better outcomes for the initial treatment of MM. Some background MM is a cancer of the plasma cells, a type...
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In a nutshell This study compared the effectiveness of CAR-T treatment for patients with diffuse large B cell lymphoma (DLBCL). The authors found that while a significant number of all patients benefitted from the treatment, some patients were more likely to benefit from it than others. Some background During initial treatment for DLBCL,...
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In a nutshell This study compared the effectiveness and safety of ABVD and BEACOPP chemotherapy for patients with advanced Hodgkin lymphoma (HL). The authors found that while BEACOPP was more effective in the short term, ABVD was as effective in the long term and safer for patients. Some background Chemotherapy is the standard initial treatment...
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In a nutshell This study investigated the effects of physical activity (PA) and long-term fatigue (tiredness) in patients with colorectal cancer. Researchers suggested that PA after the diagnosis is associated with less tiredness in these patients. Some background Colorectal cancer is the third most common cancer in men and the second in women...
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In a nutshell This study investigated the long-term effectiveness of tension-free vaginal tape obturator (TVT-O) as a treatment for urinary incontinence in women. Researchers suggested that TVT-O is a safe and highly effective option for the long-term treatment of this condition. Some background Stress urinary incontinence (SUI) affects 4 to 35% of an...
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In a nutshell This study investigated the effect of adding methotrexate (Otrexup) after adalimumab (Humira) treatment In patients with rheumatoid arthritis (RA). They found that methotrexate added to adalimumab improves disease activity (DA) in patients without previous biologic treatment. Some background Rheumatoid...
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In a nutshell This study investigated chemotherapy (CT) and stereotactic body radiotherapy (SBRT) in older patients with early-stage non-small cell lung cancer (NSCLC). They found that CT after SBRT improved survival in older patients with tumors greater than 4 cm. Some background Non-small cell lung cancer (NSCLC) is the most common form of lung...
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In a nutshell This study examined if the addition of bortezomib (Velcade) to treatment with lenalidomide (Revlimid) and dexamethasone (Decadron) could improve treatment results long-term for patients with multiple myeloma (MM). The authors found that patients who received bortezomib had a longer survival long-term. Some background...
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In a nutshell This study examined if lower numbers of platelets (blood cells involved in forming clots) and anti-clotting medications were associated with treatment results in patients with prostate cancer (PC). The authors found that lower numbers of platelets and anti-clotting medication were associated with higher treatment...
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In a nutshell This study investigated the effect of atezolizumab (Tecentriq) with chemotherapy before surgery in non-small cell lung cancer (NSCLC). They found that this treatment before surgery was safe and effective. Some background Non-small cell lung cancer (NSCLC) is the most common form of lung cancer (LC)....
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In a nutshell This study examined if biological therapies nivolumab (Opdivo) and ipilimumab (Yervoy) could safely prevent cancer return in patients with stage IV melanoma that has been surgically removed. The results showed that nivolumab and ipilimumab were effective at preventing recurrence but nivolumab alone was safer for patients. Some...
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In a nutshell This study reviewed the effectiveness and safety of phosphodiesterase type 5 inhibitors (PD5I) to treat men with erectile dysfunction. Researchers suggested that PD5I therapy improves the treatment outcomes of these patients. Some background Erectile dysfunction affects around 50% of men between 40 and 70 years. It...
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