In a nutshell This study examined if high air pollution reduced the effectiveness of exercise for patients with heart disease. The authors found that moderate to intense exercise reduced patients’ risks of heart disease and strokes regardless of air pollution. Some background Exercise is one way that patients can reduce their risks of heart...
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In a nutshell This study examined if subcutaneous (sc) injections of daratumumab (Darzalex) were as effective and safe as intravenous (iv) infusions for patients with relapsed or refractory multiple myeloma (MM). The authors found that sc injections were as effective as iv infusions and caused fewer side effects. Some background Daratumumab...
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In a nutshell This study examined if radiotherapy (RT) would benefit patients with advanced Hodgkin lymphoma (HL) with small tumors following chemotherapy. The authors found that RT may increase patients’ survival without worsening of HL, although this may also increase side effects. Some background Treatment options for patients with...
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In a nutshell This study aimed to investigate the safety and effectiveness of different chemotherapy and targeted therapy combinations given as frontline treatment in patients with chronic lymphocytic leukemia in a real-world setting. This study concluded that some treatments have a real-world activity that is comparable to clinical trial...
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In a nutshell This study examined the levels of vitamin D in patients with prostate cancer (PC) to see if they were linked to patients’ chances of survival. The results showed that patients with higher levels of active vitamin D had a greater chance of survival. Some background Vitamin D is made from sun exposure and can be found in two...
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In a nutshell This study investigated antiplatelet therapy (APT) in patients aged 70 or older with acute coronary syndrome (ACS). They found that clopidogrel (Plavix) was associated with fewer bleeding events (BEs) in these patients. Some background Acute coronary syndrome (ACS) is caused by reduced blood flow to the heart. ACS can...
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In a nutshell This study reviewed the effects of medication, psychological therapy (PT), and non-invasive brain stimulation in depression after stroke. Researchers suggested that medication and PT reduce depression and improve mood in stroke survivors. Some background A stroke happens when the blood flow to the brain is cut-off. This can be a result...
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In a nutshell The study looked at the sequence of dose-escalated radiotherapy (RT) and androgen-deprivation therapy (ADT) in the treatment of local prostate cancer (LPCa). The study found that treatment with ADT before RT had the same outcome as treatment with ADT and RT at the same time. Some background LPCa is a form of cancer that is...
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In a nutshell The study evaluated the addition of pembrolizumab (Keytruda) to etoposide (Etopophos) and platinum chemotherapy drugs for patients with untreated extensive-stage (ES) small-cell lung cancer (SCLC). The study found that pembrolizumab improved progression-free survival (PFS; survival without cancer getting worse) when added to...
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In a nutshell The study evaluated the occurrence of differentiation syndrome (DS) in patients with IDH-mutated acute myeloid leukemia (AML) under ivosidenib (Tibsovo) and enasidenib (Idhifa) therapy. The authors found that DS is a common and adverse condition in such patients. Some background Mutations or changes in the isocitrate dehydrogenase (IDH)...
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In a nutshell The report recommends how to manage patients with chronic-phase chronic myeloid leukemia (CP-CML) who failed to respond to 2nd generation tyrosine kinase inhibitors (TKIs). The authors suggested to consider patient-specific factors and personalize treatment for such patients. Some background TKIs deactivate cancerous enzymes which cause...
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In a nutshell This study looked at abemaciclib (Verzenio), trastuzumab (Herceptin), and fulvestrant (Faslodex) for the treatment of advanced hormone-receptor-positive (HR+) and HER2 positive (HER2+) breast cancer. It found that this treatment led to better outcomes than standard-of-care chemotherapy for these patients. Some background Worldwide,...
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