In a nutshell This phase 3 clinical trial tested whether everolimus (a non-hormonal treatment) added to hormone therapy with exemestane improved survival in patients with advanced breast cancer (BCa). Some background Some BCa are fueled by female sex hormones (estrogen or progesterone) that help them grow. These types of cancer are called...
Read MorePerformance status-2 – Symptomatic, 50 in bed Posts on Medivizor
Evaluating the safety and efficacy of adding oxliplatin to fluoropyrimidine chemoradiotherapy before surgery in patients with locally advanced rectal cancer
In a nutshell This review compared the efficacy and risks associated with adding oxaliplatin (OX) to fluoropyimidine (FU) chemoradiotherapy (CRT) before surgery in patients with locally advanced rectal cancer (LARC). Some background In LARC, the cancer has grown from the rectum (the lowest part of the large bowel) into surrounding...
Read MorePhase 3 clinical trial evaluating the safety and efficacy of adding docetaxel to doxorubicin and cyclophosphamide chemotherapy in node positive breast cancer patients
In a nutshell In this phase 3 clinical trial, two types of adjuvant (a treatment given in addition to a main treatment) chemotherapy regimens were compared in women with node positive breast cancer after surgery to remove the cancer. These were the combination of docetaxel (Taxotere), doxorubicin and cyclophosphamide (TDC) or the combination of...
Read MoreDoes breast cancer subtype influence the risk of recurrence in breast cancer patients?
In a nutshell This review evaluated the association between breast cancer subtypes and the risk of recurrence (return of the cancer) in breast cancer patients. Some background Breast cancers (BC) can be classified based on the presence on their surface of some proteins called receptors which can influence how these cancers work. Most BC...
Read MoreEvaluating the benefits of histamine type 2 receptor antagonists in colorectal cancer patients treated with surgery
In a nutshell The present review evaluated the benefits of histamine type 2 receptor antagonists or H2RA (a type of drugs used for the treatment of stomach ulcers) before or after surgery in patients with colorectal cancer (CRC). Some background CRC is cancer in the large intestine. In the early stages (when it is confined to the bowel), CRC is...
Read MoreIs early recurrence after surgery a poor predictor on survival in patients with colorectal cancer?
In a nutshell This study tested whether early recurrence in patients with colorectal cancer (CRC) treated with surgery can predict patients’ survival. The authors of the study found that early recurrence after surgery is associated with poorer survival in CRC patients. Some background Up to a half of CRC patients can develop a recurrence...
Read MoreThe association between lifestyle and cardiovascular disease in colorectal cancer survivors
In a nutshell The aim of this study was to assess how many colorectal cancer (CRC) survivors had a cardiovascular disease (CVD) and to determine the association between lifestyle factors and CVD. In this study overweight CRC survivors were more likely to suffer from CVD. Some background In the last years the number of CRC survivors has increased...
Read MoreFactors that influence long term survival in patients with lung metastases from colorectal cancer
In a nutshell This article looks at results from 8 clinical studies where patients had surgery to remove lung metastases. Using patient data from these studies, the authors identified risk factors which can predict the 5 year survival rate. Some background Oligometastasis defines the spread of a primary cancer (in this case colorectal cancer) to a...
Read MoreComparing the safety and efficacy of laparoscopic versus open surgery for patients with rectal cancer
In a nutshell The present study compared the safety and efficacy of laparoscopic surgery (LS) and open surgery (OS) in patients with rectal cancer. The study found that LS was as safe and effective as OS in selected patients with rectal cancer. Some background Rectal cancer is cancer in the lower part of the large intestine (rectum). Most patients...
Read MoreCan a scoring system called a nomogram help develop a treatment program that is individual to each patient?
In a nutshell This article is a short editorial describing how the use of a “nomogram” (a predictive tool based on a points system) could provide a doctor and patient with possible outcomes if different treatment options are selected. Some background The current method of choosing treatment for patients with rectal cancer is fairly...
Read MoreThe use of genetic testing for selecting the best treatment for early-stage breast cancer
In a nutshell The aim of this article was to discuss the way in which the latest results on cancer DNA research apply to early-stage breast cancer. Genome analysis is highly likely to play a growing role in the future but more clinical trials are needed. Some background Breast cancer is a disease with multiple symptoms and consequences that are...
Read MoreRobotic radiation treatment compared to radiofrequency ablation for the treatment of liver metastases from colorectal cancer
In a nutshell This article compares the use of radiofrequency ablation (RFA) and a robotic method of treatment using directed radiation to liver metastases from colorectal cancer which have been deemed not suitable for surgical treatment. The study shows robotic radiation treatment is safe and comparable to RFA, with a trend towards being better...
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