In a nutshell This phase II clinical trial tested whether a new drug, entinostat, can work in concert with exemestane (a hormone therapy drug), to fight breast cancer that no longer responds to hormone therapy alone. Some background Some breast cancers need estrogen (a female sex hormone) to grow. These breast cancer cells respond to estrogen via...
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Phase II clinical trial evaluating the effects of anti-inflammatory drug celecoxib as treatment for breast cancer patients
In a nutshell This phase II clinical trial evaluated the effect of the drug celecoxib (Celebrex) as treatment for patients with breast cancer. Some background Inflammation is one of the body's natural responses to injury and may play a role in cancer formation. Inflammation is controlled in part by a type of hormone produced by cells...
Read MoreDoes breast cancer type and hormone status influence the efficacy of hormone therapy in breast cancer patients?
In a nutshell This study evaluated the efficacy of hormone therapy in patients with two types of breast cancer, invasive ductal breast carcinomas (IDC) and invasive lobular breast carcinomas (ILC) based on hormonal status. Some background Breasts are made up of lobules (milk-producing glands) and ducts (tubes that carry the milk to the...
Read MorePhase 3 clinical trial evaluating the safety and efficacy of adding docetaxel to doxorubicin and cyclophosphamide chemotherapy in node positive breast cancer patients
In a nutshell In this phase 3 clinical trial, two types of adjuvant (a treatment given in addition to a main treatment) chemotherapy regimens were compared in women with node positive breast cancer after surgery to remove the cancer. These were the combination of docetaxel (Taxotere), doxorubicin and cyclophosphamide (TDC) or the combination of...
Read MoreEvaluating the benefits of histamine type 2 receptor antagonists in colorectal cancer patients treated with surgery
In a nutshell The present review evaluated the benefits of histamine type 2 receptor antagonists or H2RA (a type of drugs used for the treatment of stomach ulcers) before or after surgery in patients with colorectal cancer (CRC). Some background CRC is cancer in the large intestine. In the early stages (when it is confined to the bowel), CRC is...
Read MoreComparing the outcomes of laparoscopic versus open surgery in patients with colorectal cancer
In a nutshell This study compared the short- and long-term outcomes of two types of surgery for patients with colorectal cancer (CRC): open surgery (OS) versus laparoscopic surgery (LS). LS led to less pain following surgery, shorter hospital stays, faster recovery times, and improved survival rates. Some background CRC is very common,...
Read MoreIs early recurrence after surgery a poor predictor on survival in patients with colorectal cancer?
In a nutshell This study tested whether early recurrence in patients with colorectal cancer (CRC) treated with surgery can predict patients’ survival. The authors of the study found that early recurrence after surgery is associated with poorer survival in CRC patients. Some background Up to a half of CRC patients can develop a recurrence...
Read MoreCan a scoring system called a nomogram help develop a treatment program that is individual to each patient?
In a nutshell This article is a short editorial describing how the use of a “nomogram” (a predictive tool based on a points system) could provide a doctor and patient with possible outcomes if different treatment options are selected. Some background The current method of choosing treatment for patients with rectal cancer is fairly...
Read MoreCombination of Anastrozole and Fulvestrant therapy in hormone receptor positive metastatic breast cancer
In a nutshell This study compared the effect of two regimens for hormone-positive, metastatic breast cancer on disease progression and survival: a combination of two drugs, namely anastrozole (Arimidex) and fulvestrant (Faslodex), versus anastrozole alone. Some background Breast cancers often require estrogen (the female sex...
Read MoreRobotic radiation treatment compared to radiofrequency ablation for the treatment of liver metastases from colorectal cancer
In a nutshell This article compares the use of radiofrequency ablation (RFA) and a robotic method of treatment using directed radiation to liver metastases from colorectal cancer which have been deemed not suitable for surgical treatment. The study shows robotic radiation treatment is safe and comparable to RFA, with a trend towards being better...
Read MoreA potential new treatment for triple negative breast cancer: Blocking TGF-beta may improve the outcomes of chemotherapy
In a nutshell This laboratory based study investigates the use of compounds which block TGF-β signalling in triple negative breast cancer cells. They show that inhibiting this process prevents the development of paclitaxel resistance and the recurrence of cancers following paclitaxel treatment. Some background Triple negative...
Read MoreThe link between tumor response 8 weeks into the treatment and overall survival in metastatic breast cancer patients treated with first-line chemotherapy
In a nutshell The aim of this article was to determine if the initial shrinking of tumors due to combined chemotherapy is correlated with overall survival (OS) in patients with metastatic breast cancer (MBC – spread to other organs). Some background OS (survival at the end of the treatment) is the best parameter to evaluate treatment...
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