In a nutshell The authors evaluated 1-year differences in outcome between 4 different treatments for bone mass loss associated with androgen deprivation therapy. Some background Androgen deprivation therapy (ADT) is the cornerstone of treatment for metastatic prostate cancer (cancer that has spread beyond the prostate), high-risk early-stage...
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In a nutshell This study explored the use of metformin (Glucophage) in prostate cancer patients undergoing androgen-deprivation therapy. Some background Prostate cancer is often dependent on androgens, or male hormones such as testosterone, for growth. Therefore, a standard treatment in advanced or metastatic (spread of disease to...
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In a nutshell This study examined the effectiveness of combined androgen blockade in the treatment of prostate cancer. Some background Prostate cancer is often dependent on androgens (male hormones such as testosterone, DHEA-S and andosterone) for growth. Therefore, the mainstay of prostate cancer treatment is androgen deprivation therapy,...
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In a nutshell This review analyzed the role of estrogen therapy in increasing sexual function among prostate cancer patients undergoing androgen deprivation therapy. Some background Prostate cancer cells rely on androgens (hormones such as testosterone) to grow. Therefore, a common therapy used to slow prostate cancer growth is androgen...
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In a nutshell This study investigated the risk of heart attacks and diabetes among prostate cancer patients, with and without co morbidities, receiving androgen deprivation therapy (ADT). Some background Androgen-deprivation therapy (ADT) is a commonly used treatment for prostate cancer. Since prostate cancer growth is stimulated by androgen...
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In a nutshell This study evaluated the results of early salvage radiation therapy (ESRT) in prostate cancer patients after radical prostatectomy. Some background Following radical prostatectomy (surgical removal of the prostate gland), prostate cancer often recurs and requires further treatment. Surveillance for cancer recurrence is usually...
Read MoreIn a nutshell This study investigated the combined treatment of tamoxifen (nolvadex) and goserelin (zoladex) in women diagnosed with early stage hormone receptor positive breast cancer. Some background Growth of hormone receptor positive (HR+) breast cancer is stimulated by the hormone estrogen. Tamoxifen is an oral drug commonly used to treat HR+...
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In a nutshell This article investigated whether the body mass index or BMI (defined as weight divided by the square of height) can be used to determine how a patient with breast cancer treated with hormonal therapy may benefit from further treatment with a type of hormonal therapy called aromatase inhibitors. Some background Aromatase inhibitors...
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In a nutshell This review summarizes the common adverse effects of everolimus (afinitor) treatment and covers the recommend management of each of these. Some background Everolimus is a drug sometimes used to treat hormone receptor positive (HR+) breast cancer patients in addition to standard hormonal treatment. Everolimus inhibits the immune...
Read MoreIn a nutshell This study examined whether androgen deprivation therapy given as treatment for prostate cancer patients increases the risk of kidney injury. Some background Androgens are a group of hormones (such as testosterone) which can stimulate the growth and spread of prostate cancer cells. Androgen deprivation therapy (ADT) reduces the...
Read MoreIn a nutshell This phase 3 clinical trial assessed the efficacy and safety of chemotherapy drug docetaxel combined with hormone therapy (androgen deprivation therapy or ADT) in patients with metastatic non-castrate prostate cancer. Some background Androgens (testosterone) are male sex hormones that control the development and maintenance...
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In a nutshell This study examined the impact on survival of more than 5 years of adjuvant hormonal therapy in breast cancer patients. Some background Some types of breast cancer grow in response to female sex hormones (estrogen and progesterone) via their receptor (a protein found on breast cells). These are called hormone receptor-positive (HR+)...
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