In a nutshell This study investigated the safety and effectiveness of a chemotherapy regimen alternating R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) and R-cytarabine (rituximab combined with cytarabine) for mantle cell lymphoma (MCL) patients ineligible for stem cell transplant (SCT). This study concluded that alternating...
Read MoreIn a nutshell This study aimed to compare two conditioning treatment regimens for adult patients with Ph-negative acute lymphoblastic leukemia treated with stem cell transplant. This study concluded that the regimen that combined etoposide (Etopophos) and total body irradiation was more effective than the regimen that combined cyclophosphamide (Neosar)...
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In a nutshell This study aimed to investigate the use of stem cell transplant with a chemotherapy treatment regime in patients with acute myeloid leukemia. This study concluded that this regime is safe and effective in patients that receive stem cell transplants from a haploidentical (half or partially matched) donor. Some background The use of...
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In a nutshell This study aimed to find out if radiation added to standard chemotherapy could increase the response to treatment for locally advanced breast cancer. This study found that neoadjuvant radiation added to chemotherapy improved response but not overall survival. Some background Chemotherapy is a treatment option for...
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In a nutshell This study examined a new treatment combination known as RCC followed by rituximab (Rituxan) maintenance therapy for chronic lymphocytic leukemia (CLL). These results support the safety and effectiveness of RCC followed by rituximab maintenance therapy. Risk factors of disease progression were identified. Some background The chemotherapy...
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In a nutshell This study aimed to investigate the prevalence of metabolic syndrome in adult survivors of childhood acute leukemia. This study also aimed to determine the effect of different therapies on the occurrence of metabolic syndrome in these patients. This study concluded that metabolic syndrome is frequent among childhood AL survivors, regardless...
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In a nutshell This study aimed to investigate the incidence and risk factors for osteonecrosis in pediatric patients with acute lymphoblastic leukemia in Asia. This study concluded that the incidence of osteonecrosis is low and the only risk factor is aged 10 years or older in these patients. Some background Osteonecrosis (ON) occurs when there...
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Video information: Precision medicine allows for treatment plans to line up with a specific genetic profile. Find out from Dr. Michael Keating what is used to target CLL patients with a 17p deletion and when treatment should generally start. Dr. Keating also shares other genetic mutations to be aware of, and which tests are used to locate...
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Video information: Inhibitors and targeted therapies have changed the landscape of CLL treatment, so what can patients expect from modern medicine? Dr. Jeff Sharman, from the US Oncology Network, joins our panel to explain the difference in design between newer therapies and chemotherapy. He also shares what newer medicines, like ibrutinib...
Read MoreIn a nutshell This study evaluated the effectiveness of filgrastim (Neupogen) as compared to original G-CSF treatments lenograstim and pegfilgrastim (Neulasta). The study concluded that filgrastim was as effective as original G-CSF treatments. Some background Low white blood cell counts can occur...
Read MoreIn a nutshell This study aimed to compare the effectiveness of myeloablative conditioning and reduced intensity conditioning before hematopoietic stem cell transplant in acute myeloid leukemia patients. This study concluded that myeloablative conditioning was more effective than reduced intensity conditioning. Some background A...
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In a nutshell This trial examined the antiemetic drug NEPA (Akynzeo) at combating chemotherapy induced nausea and vomiting in patients with lung cancer. The authors concluded that NEPA is effective at reducing nausea and is well tolerated in these patients. Some background For many cancers, chemotherapy is the gold standard for treatment....
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