In a nutshell This study aimed to compare the outcomes of patients with chronic lymphocytic leukemia who received chemoimmunotherapy or ibrutinib. This study suggested that ibrutinib may have more favorable outcomes for these patients when compared to chemoimmunotherapy. Some background Chemoimmunotherapy (CIT) is a treatment option that can be used...
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Is a low-intensity chemotherapy treatment plan safe and effective for elderly patients with Acute Myeloid Leukemia?
In a nutshell This study aimed to create a safe and effective low-intensity chemotherapy treatment plan for elderly patients with AML . This is an ongoing clinical trial and so far the authors have found the therapy has been safe and effective. Some background Outcomes for elderly patients with AML in the past have not been good due to the high...
Read MoreEvaluating rituximab maintenance therapy in patients with newly diagnosed follicular lymphoma
In a nutshell This study evaluated the effectiveness of rituximab (Rituxan) maintenance therapy in patients with newly diagnosed follicular lymphoma (FL). This study concluded that this therapy improves survival outcomes in these patients. Some background For patients with early (stage 1 – 2) FL, aggressive radiotherapy or...
Read MoreEvaluating the outcomes after second-line therapy for relapsed or refractory PMBCL
In a nutshell This study investigated the outcomes of pretreated patients with relapsed (cancer recurrence) or refractory (does not respond to treatment) primary mediastinal large B-cell lymphoma (PMBCL) after second-line therapy and stem cell transplant (SCT). The study concluded that this treatment strategy was effective in most patients. Some...
Read MoreOutcomes of salvage therapy for patients with chronic lymphocytic leukemia
In a nutshell This study aimed to investigate outcomes of salvage therapy after treatment with fludarabine, cyclophosphamidine and rituximab fails in patients with chronic lymphocytic leukemia. This study concluded that salvage therapy can provide excellent outcomes for these patients. Some background Fludarabine (Fludara) is a chemotherapy used...
Read MoreEvaluating venetoclax with BR for the treatment of relapsed or refractory non-Hodgkin’s lymphoma
In a nutshell This study evaluated the safety and effectiveness of venetoclax (Venclexta) plus BR (bendamustine, rituximab) in patients with relapsed or refractory (does not respond to treatment) non-Hodgkin’s lymphoma (NHL). This study concluded that this treatment was tolerated and showed promising effectiveness in these patients. Some...
Read MoreComparing obinutuzumab and rituximab in first-line chemotherapy regimens for follicular lymphoma
In a nutshell This study investigated the safety and effectiveness of obinutuzumab (Gazyva) versus rituximab (Rituxan) plus chemotherapy for previously untreated follicular lymphoma. This study concluded that obinutuzumab improved survival outcomes compared to rituximab. Some background Follicular lymphoma is the most common type of...
Read MoreDoes 8 cycles of R-CHOP lead to better survival than 6 cycles for diffuse large B-cell lymphoma?
In a nutshell This study examined whether 6 or 8 cycles of R-CHOP-21 (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy led to better survival outcomes in patients with newly diagnosed diffuse large B-cell lymphoma. This study concluded that outcomes following 6 or 8 cycles of R-CHOP-21 are similar for these patients. Some...
Read MoreDoes bendamustine treatment increase risk of infections in non-Hodgkin Lymphoma?
In a nutshell This study looked at the risk of infection in older patients with indolent non-Hodgkin lymphoma (nHL) treated with bendamustine (Treanda). Researchers concluded that nHL patients treated with bendamustine had increased risk of common bacterial, fungal, and viral infections. Some background Bendamustine is a chemotherapy drug sometimes...
Read MoreLenalidomide and blood clots: low risk in CLL and NHL
In a nutshell This study examined the risk of venous thromboembolism (VTE, a blood clot that forms in the veins of the legs, arms, or groin) in patients treated with lenalidomide (Revlimid). The study concluded that the risk of VTE was low with lenalidomide treatment. Some background Lenalidomide is an effective treatment already used in multiple...
Read MorePreventing invasive fungal infections in acute leukemia patients
In a nutshell This study aimed to compare the effectiveness and tolerability of micafungin (Mycamine) and posaconazole (Noxafil) in acute leukemia patients undergoing chemotherapy. This study concluded that micafungin was effective as an antifungal prophylaxis in these patients. Some background Invasive fungal infections (IFIs) are...
Read MoreDoes G-B treatment improve survival outcomes for patients with refractory follicular lymphoma?
In a nutshell This study investigated the outcomes of patients with indolent (painless) refractory (does not respond to treatment) non-Hodgkin’s lymphoma (NHL) after G-B (obinutuzumab, bendamustine) treatment. This study concluded that G-B improved survival outcomes for NHL patients with similar side effects as bendamustine (Treanda)...
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