In a nutshell This study aimed to compare the outcomes of allogeneic hematopoietic cell transplant (alloHCT) for older patients with acute myeloid leukemia (AML) using treosulfan (Trecondi) compared to reduced intensity busulfan (Myleran) conditioning. This study concluded that treosulfan conditioning appears to be more suitable for...
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Evaluating the safety and effectiveness of optimized conformal total body irradiation in children with with blood cancer who received TCRαβ/CD19-depleted grafts
In a nutshell The study aimed to investigate optimized conformal (OC) total body irradiation (TBI) in pediatric patients with blood cancers who received further chemotherapy and allogeneic hematopoietic stem cell transplant (alloHSCT) with TCRαβ/CD19 depletion. This study concluded that OC-TBI is a...
Read MoreComparing the long-term outcomes of umbilical cord blood donor versus unrelated donor transplantation in patients with acute myeloid leukemia.
In a nutshell This study compared the long-term outcomes of umbilical cord (UC) blood transplantation versus unrelated donor transplantation (UD) in patients with acute myeloid leukemia (AML). The data showed that long-term outcomes for patients in complete remission two years after transplantation was not impacted by donor...
Read MoreConsolidation chemotherapy before reduced intensity allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia
In a nutshell This study aimed to investigate if consolidation chemotherapy before reduced-intensity conditioning (RIC) allogeneic hemopoietic stem cell transplant (alloHSCT) improved outcomes for patients with acute myeloid leukemia (AML). This study concluded that exposure to consolidation chemotherapy before RIC alloHSCT may help patients...
Read MoreAllogenic versus autologous hematopoietic stem cell transplant for patients with acute promyelocytic leukemia
In a nutshell This study aimed to compare the outcomes of allogeneic (allo) and autologous (auto) hematopoietic stem cell transplant (HSCT) for patients with acute promyelocytic leukemia (APL) in second complete remission (CR2). This study concluded that autoHSCT resulted in better outcomes for these patients. Some background...
Read MoreCan lenalidomide maintenance improve survival after autologous hematopoietic stem-cell transplantation in patients with mantle cell lymphoma?
In a nutshell This study investigated whether lenalidomide maintenance therapy after intensive chemoimmunotherapy and first-line autologous hematopoietic stem-cell transplantation (AHSCT) improved the outcomes of patients with mantle cell lymphoma (MCL). The data showed that lenalidomide maintenance after AHSCT improved the survival without...
Read MoreRecombinant human granulocyte colony-stimulating factor and decitabine treatment delay relapse after transplant for patients with acute myeloid leukemia
In a nutshell This study aimed to investigate if the combination of recombinant human granulocyte colony-stimulating factor (rhG-CSF; Filgrastim) and decitabine (Dacogen) would be effective in preventing relapse after transplant for patients with high-risk (HR) acute myeloid leukemia (AML). This study...
Read MoreEvaluating sorafenib maintenance therapy in patients with acute myeloid leukemia with FLT3-ITD mutation undergoing allogeneic HSCT
In a nutshell The study evaluated outcomes of sorafenib (Nexavar) maintenance therapy after allogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML) carrying FLT3-ITD mutation (abnormal gene). The authors found that this therapy was effective and tolerable after aHSCT in such patients. Some...
Read MoreDoes donor type impact on outcomes of stem cell transplant for very high-risk acute lymphoblastic leukemia pediatric patients?
In a nutshell This study aimed to investigate if donor type impacts on the overall outcomes of allogeneic stem cell transplant for children with very high-risk acute lymphoblastic leukemia. This study concluded that donor type does impact on these patients and that worse outcomes are seen with mismatched donors. Some...
Read MoreEvaluating antithymocyte globulin in preventing graft-versus-host-disease after matched sibling donor transplantation
In a nutshell This study aimed to investigate the role of antithymocyte globulin in preventing graft-versus-host disease after matched sibling donor transplantation. This study concluded that this treatment can reduce the occurrence of graft-versus-host-disease in these patients. Some background One...
Read MoreEvaluating antithymocyte globulin in preventing graft-versus-host-disease after matched sibling donor transplantation
In a nutshell This study aimed to investigate the role of antithymocyte globulin in preventing graft-versus-host disease after matched sibling donor transplantation. This study concluded that this treatment can reduce the occurrence of graft-versus-host-disease in these patients. Some background One treatment option for patients with blood...
Read MoreImpact of graft cryopreservation on allogeneic hematopoietic stem cell transplant outcomes using post-transplant cyclophosphamide
In a nutshell This study aimed to compare outcomes of allogeneic hematopoietic stem cell transplant (alloHSCT) using cryopreserved (frozen) and fresh grafts in patients with blood cancers who received post-transplant cyclophosphamide (Cytoxan). This study concluded that cryopreservation (CP) does not affect the outcomes of HSCT in these patients....
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