In a nutshell This study examined the effectiveness of onartuzumab (MetMAb) and erlotinib (Tarceva) as treatment for non-small cell lung cancer patients. Some background Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. In many patients, a mutation in the EGFR gene, which is involved in...
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In a nutshell This study evaluated the use, effects and adherence of trastuzumab (herceptin) as treatment for patients with breast cancer. Some background Trastuzumab is often prescribed as adjuvant (additional) therapy for human epidermal growth factor receptor-2 positive (HER2+) breast cancer. HER2 is a protein found on the surface of some...
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In a nutshell This review examined the combination of several chemotherapy agents with bevacizumab (Avastin) in the treatment of patients with advanced colorectal cancer. Some background Advanced cases of colorectal cancer (CRC) are generally treated with chemotherapy in addition to surgery. A combination of three drugs, 5-fluorouracil,...
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In a nutshell This study assessed the impact of pathologic complete response (pCR) to neoadjuvant chemotherapy and trastuzumab (herceptin) on survival of HER2-positive breast cancer patients. Some background Neoadjuvant therapy refers to treatments given before surgery in order to shrink the tumor and allow for complete surgical removal of the...
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In a nutshell This study compared two treatment strategies for advanced non-small cell lung cancer: platinum analog chemotherapy plus the drug bevacizumab (avastin) versus platinum analog chemotherapy alone. Some background Treatment for advanced non-small cell lung cancer typically involves treatment with chemotherapy. Standard chemotherapy...
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In a nutshell This phase III trial compared chemotherapy to erlotinib (Tarceva) as first line treatment for EGFR-positive non-small cell lung cancer (NSCLC) patients. The safety and efficacy of the treatments were compared to decide which treatment is most beneficial for advanced cancer patients. Some background Non-small-cell lung cancer (NSCLC)...
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In a nutshell This article evaluated the use of bevacizumab alongside chemotherapy in patients with metastatic colorectal cancer after the progression of the disease following treatment with bevacizumab. Some background Cancer cells need blood supply in order to grow. They do so by forming new blood vessels thereby feeding...
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