In a nutshell The authors assessed the role of amputation (removal) in the management of melanoma in limbs (arms or legs). Some background There are many treatment options available for patients with limb melanoma. Isolated limb perfusion (ILP) is one of the most common and effective treatments for limb melanoma. In ILP, high doses of chemotherapy...
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In a nutshell The authors evaluated the effectiveness of a combination therapy of vemurafenib (Zelboraf) and cobimetinib (Cotellic) for the treatment of advanced melanoma. Some background In advanced melanoma (stage 3/4), cancer spreads from the skin to other parts of the body. Targeted therapy has shown improved outcomes in these stages...
Read MoreIn a nutshell The authors analyzed the patterns of survival and recurrence in patients with scalp (the skin covering the head but not the face) melanoma. Some background Head and neck skin melanomas occur in less than 20% of all cases. It is associated with worse outcome than melanoma of other body parts. Scalp melanoma is part of head and neck...
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In a nutshell The authors determined the factors that predict response to melphalan (Alkeran) delivered through isolated limb infusion (a technique to apply drugs at the tumor sites in melanoma). Some background Melanoma is sensitive to chemotherapy drugs, resulting in higher occurrences of adverse events. But the disease requires higher dose...
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In a nutshell The authors analyzed the effect of combination treatment with inerleukin-2 (Proleukin) injected in skin, with imiquimod (Zyclara) ointment in advanced skin cancer. Some background In advanced skin melanoma (stage III/IV), cancer spreads rapidly from the skin to the surrounding lymph nodes and the lymphatic channels (important part of...
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In a nutshell The authors analyzed the effectiveness of ipilimumab (Yervoy) combined with fotemustine (Muphoran) in advanced melanoma patients. Some background In advanced melanoma (stage III/IV), cancer spreads rapidly from the skin to other parts of the body. This is known as...
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In a nutshell The authors analyzed the adverse effect of combination treatment with radiation and targeted therapy in melanoma. Some background In advanced melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. In the majority of advanced melanoma patients, BRAF genes are mutated...
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In a nutshell The authors evaluated the effect of dabrafenib (Tafinlar) in disease progression in melanoma patients with cancer that has spread to the brain (metastasis). Some background In advanced melanoma (stage III/IV) cancer spreads from the skin to other parts of the body, most commonly, to the brain. In...
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In a nutshell The authors evaluated the effectiveness of combination therapy in advanced melanoma patients with mutated (permanent changes) BRAF genes. Some background In advanced melanoma (stage III/ IV), cancer spreads from the skin to other parts of the body. Targeted therapy has been shown to improve patient outcomes in the advanced...
Read MoreIn a nutshell The authors reviewed different immunotherapies for advanced melanoma. Some background In advanced melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. Immunotherapy is a common treatment used in advanced melanoma. It uses the body’s own immune system to fight cancer. This...
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In a nutshell The authors analyzed the role of certain genes in predicting survival in melanoma patients treated with tremelimumab (CP-675,206). Some background In advanced melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. Immunotherapy is an effective treatment for advanced melanoma. It uses the...
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In a nutshell The authors analyzed the effectiveness of standard melanoma treatments in the management of acral melanoma (a type of skin cancer affecting specific parts of a body). Some background Acral melanoma affects the skin of the limbs, ears, fingers or nails. The occurrence of acral melanoma is most common in people with darker...
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