In a nutshell This study looked at the use of surgery for spread disease (metastases) in patients with advanced melanoma when other whole-body treatments had failed. It found that surgical removal of metastases improved the outcomes of these patients. Some background Advanced melanoma can spread to many places in the body. It is usually...
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In a nutshell The aim of this study was to check the safety and effectiveness of the combination of ipilimumab (Yervoy) and radiotherapy (RT) in patients with high-risk melanoma. The study found that ipilimumab + RT was safe and had good responses in these patients. Some background Melanoma is a type of skin cancer. First line therapy for...
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In a nutshell This study looked at the effectiveness of immune therapy in patients aged over 65 with advanced melanoma. They found that immune therapy led to longer survival times than other treatments such as chemotherapy. Some background Immune therapy has improved the outlook for patients with advanced skin melanoma. These medications...
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In a nutshell This trial is looking at the effectiveness, safety, and tolerability of ladiratuzumab vedotin (LV) in patients with advanced solid tumors, including melanoma. The main outcome to be measured in this trial is the response rate to the new drug. The details Advanced tumors have spread from the organ where they originated....
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In a nutshell This study presents updated longer-term data on recurrence-free survival (RFS) for pembrolizumab (Keytruda) after surgery for stage 3 melanoma. The study showed that pembrolizumab has a lasting and improving effect on RFS as a treatment after surgery. Some background For patients with stage 3 melanoma,...
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In a nutshell This study compared nivolumab (Opdivo) and ipilimumab (Yervoy) for treating advanced melanoma that has been surgically removed. They found that patients treated with nivolumab survived cancer-free for longer than patients treated with ipilimumab. Some background Melanoma which has spread to the lymph nodes or other organs is...
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In a nutshell This study looked at the effects after stopping immune therapy in patients with advanced melanoma. They found that responses to treatment lasted long after treatment was stopped. Some background Stage 3 or 4 melanoma refers to a tumor that has spread to lymph nodes or distant organs. At this advanced stage, the cancer...
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In a nutshell This study evaluated the safety and effectiveness of dabrafenib (Tafinlar) and trametinib (Mekinist) together before surgery to remove stage three melanoma. The study found that a high proportion of patients treated in this way had no signs of cancer left. Some background Dabrafenib and trametinib are...
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In a nutshell This study investigated the use of circulating tumor DNA (ctDNA) to predict treatment response in advanced melanoma. They found that ctDNA levels can predict survival in these patients. Some background Melanoma is categorized, like many cancers, in stages. At stage 3 and above, survival rates can vary depending on...
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In a nutshell This study wanted to find out if performing ultrasounds and performing clinical exams is a safe option to catch cancer that has spread to the lymph nodes in patients with melanoma. The study found that a significant number of tumors were found in lymph nodes by performing this type of surveillance. Some background The most common...
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In a nutshell This study evaluated the safety and effectiveness of talimogene laherparepvec (TVEC) therapy for patients with melanoma that cannot be surgically removed (unresectable). The study found that TVEC therapy is an effective treatment for these patients, with minimal side effects. Some background Patients with localized melanoma that is...
Read MoreIn a nutshell This study wanted to find out how well a new cancer treatment called T-VEC works in patients with melanoma that cannot be surgically removed. The study found that this treatment is very effective in patients with melanoma that cannot be surgically removed. Some background T-VEC is short for talimogene laherparepvec. This is a new type of...
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