In a nutshell This study looked at the effectiveness of a surgical treatment called partial transscleral sclerouvectomy (PTSU) combined with microinvasive vitrectomy and reconstruction of the eyeball (MIVR) for the treatment of tumors within the eyeball. This showed that this treatment can be effective for most eye tumors. Some background Melanoma is...
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In a nutshell This study investigated if nivolumab (Opdivo) is safe and effective in patients with rare melanoma subtypes (RMS) who progressed after ipilimumab (Yervoy). They found that this treatment was safe and improved survival in certain RMS. Some background Melanoma the most common cancers. There are many subtypes...
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In a nutshell The authors evaluated the effect of percutaneous hepatic perfusion (PHP, a method of treating melanoma that has spread to the liver) with melphalan (Alkeran). This study found that PHP with melphalan improved outcomes in melanoma patients with cancer spread to the liver. Some background In advanced melanoma (stage 3/4), cancer...
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In a nutshell The authors analyzed the complications and outcomes of radiation therapy in specific eye melanoma. Some background Choroidal melanoma develops in the choroid (the sponge-like membrane at the back of the eye). It is the most common eye cancer in adults. Juxtapapillary choroidal melanoma affects the optic...
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In a nutshell The authors assessed the effectiveness of a specific radiation therapy called plaque brachytherapy in treating eye melanoma. Some background Uveal melanoma is cancer (melanoma) of the eye involving three parts of an eye (iris, ciliary body or choroid) – together known as the uvea. Chorodial melanoma is...
Read MoreIn a nutshell The authors aimed to determine the effects of BAP1 protein in uveal melanoma. Some background Uveal melanoma is a rare form of cancer that occurs in the eye. BAP1 protein is involved in cell development and growth in healthy cells. Research has shown that patients who lack the BAP1 protein have an increased risk of tumor...
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In a nutshell The authors aimed to determine patient outcomes using the standard classification systems in uveal melanoma patients. Some background Uveal melanoma is a rare form of cancer that occurs in the eye. The TNM classification system can be used to determine the extent of melanoma present and can help identify the most effective...
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In a nutshell The authors aimed to determine the effect of hepatic intra-arterial (HIA) compared to intravenous (IV) fotemustine (Muphoran) treatment in patients with liver tumors from uveal melanoma. Some background Uveal melanoma is a rare form of cancer that occurs in the eye. In 5% of patients this will lead to cancer spread into other parts...
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In a nutshell This analysis evaluated the efficacy and safety of ipilimumab in treatment of patients with metastatic uveal melanoma. Some background Ocular melanoma or uveal melanoma is a cancer of the eye. Tumors arise from the pigment cells (melanocytes) that reside within the uvea giving color to the eye. Once metastasis...
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In a nutshell This phase II clinical trial assessed the efficacy of a treatment called isolated hepatic perfusion (IHP) for the treatment of patients with liver metastases from ocular melanoma. Some background Ocular (uveal) melanoma is cancer of the pigmented cells (called melanocytes) of the eye. Although most patients undergo successful...
Read MoreIn a nutshell This review analyzed data from several recent trials, and determined the benefit of liver resection (surgery to remove part or all of the liver) in patients with metastatic melanoma. Some background Melanoma is an uncontrolled growth of skin cells, but this cancer may also spread to other organs (referred to as metastatic melanoma)....
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