In a nutshell This study compared the efficacy and safety of two drug regimens in patients with advanced colorectal cancer. Some background Cetuxima (Erbitux) prolongs survival of patients with metastatic (spread beyond the original location of the tumor) colorectal cancer. The effects of cetuximab in combination with chemotherapy regimens that...
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In a nutshell The authors analyzed the effectiveness of continued treatment with dabrafenib (Tafinlar) and vemurafenib (Zelboraf) in advanced melanoma after disease progression despite treatment with these drugs. Some background In advanced melanoma (stage 3/4), cancer spreads from the skin to other parts of the body. BRAF genes are...
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In a nutshell The authors analyzed the patterns of relapse in patients with head and neck melanoma treated with surgery and radiation therapy. Some background Skin melanoma of head and neck is often associated with poor survival. Surgical removal of the affected lymph nodes (tiny, bean-shaped organ that help fight infection) along with the...
Read MoreIn a nutshell This study examined whether high intensity exercise could improve the cardiometabolic profile in women with polycystic ovary syndrome. Some background Polycystic ovarian syndrome (PCOS) is associated with many hormonal and metabolic (how the body breaks down and uses energy from food) factors. In addition to having fertility problems...
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In a nutshell This review examined whether patient education can prevent foot ulcers in diabetics. Some background Chronic high blood glucose (sugar) levels in patients with diabetes can result in damage to small blood vessels, leading to various vascular complications. Damage to small blood vessels in the foot can lead to a diabetic...
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In a nutshell This study determined whether eating disorders and depression are associated with control of blood glucose levels in young adults with type 1 diabetes. Some background Patients with type 1 diabetes (T1D) are four times more likely to have depression compared to those who do not have T1D. Eating disorders are also common among T1D...
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In a nutshell This study examined the effects of luseogliflozin on blood glucose levels over a 24-hour period. Some background Luseogliflozin (Lusefi) is new treatment for type 2 diabetes (T2D) that prevents glucose (sugar) from being reabsorbed back into the blood from the urine and, therefore, reduces blood glucose levels....
Read MoreIn a nutshell This study investigated whether response to lifestyle changes can be predicted in prediabetic patients. Some background Prediabetes is a condition in which blood glucose (sugar) levels are higher than normal but not high enough to be considered type 2 diabetes (T2D). Patients with prediabetes produce insulin but have insulin...
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In a nutshell This study examined the impact of high-intensity intermittent exercise on the heart and liver of patients with type 2 diabetes. Some background Patients with type 2 diabetes (T2D) have a higher risk of developing cardiovascular disease (CVD). CVD is the narrowing or blockage of blood vessels due to the build-up of fatty plaque...
Read MoreIn a nutshell This paper reviewed the management of spontaneous intracerebral hemorrhage. Some background Spontaneous intracerebral hemorrhage refers to a blood clot that arises within the brain. It is spontaneous, meaning that there has been no trauma or surgery. This is associated with a greater risk of death compared to other causes of...
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In a nutshell This paper studied the safety and effectiveness of polymer-free and carrier-free drug-coated stent that releases umirolimus (Biolimus A9) in patients at high risk of bleeding. Some background Stents are small devices placed in blood vessels to prevent obstruction of blood flow. They can be bare metal stents (mesh stent) or...
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In a nutshell This study reviewed the effects of statin therapy on erectile function. Some background Erectile dysfunction (ED) is especially common among men with risk factors such as diabetes, high cholesterol and heart disease. Cholesterol lowering drugs called statins are often used to treat such risk factors. Improvement of pre-existing...
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