In a nutshell This study looked at the effects of maternal and paternal exposure to the drug abatacept (Orencia). Based on the data, there were no increased instances of birth abnormalities. Some background Rheumatoid arthritis (RA) is a chronic autoimmune disease which causes inflammation of the joints. Medications used to treat...
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In a nutshell This study aimed to determine whether there was an association between migraines and cryptogenic transient ischemic attack (TIA) or ischemic stroke. The researchers determined that there is a causal link between migraine and cryogenic TIA or ischemic stroke, particularly in older people. Some background Ischemic stroke occurs when a...
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In a nutshell This trial investigated the effect of empagliflozin (Jardiance) on daily glucose levels in people with type 1 diabetes mellitus (T1DM). Some background Empagliflozin is a drug approved for the treatment of type 2 diabetes. It causes sugar in the blood to be released from the body via the urine. However, recent studies...
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In a nutshell This study investigated whether certain markers were associated with local recurrence or survival post-surgery in early stage colorectal cancer patients. This trial determined that certain factors were associated with a higher risk of local recurrence (including male gender and current alcohol use) and surivival times (including age of...
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In a nutshell This study explored the relationship between gestational diabetes (GD) and polycystic ovarian syndrome (PCOS). This study concluded that there was a two-fold increase in the rate of GD in women who had PCOS compared to women without PCOS. Some background PCOS is a common disorder, affecting between 5% and 14% of women during their...
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Cognitive side effects to chemotherapy, often called “chemobrain” or “chemofog”, are a growing concern among cancer survivors. Symptoms such as a decline in memory, concentration and executive functions (such as organization or attention) are often described. Cognitive changes can cause significant distress and prevent a return to...
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In a nutshell The authors aimed to determine the effect of docetaxel (Taxotere – a type of chemotherapy) and hormone therapy in patients with metastatic (cancer that has spread) prostate cancer. Some background Chemotherapy and hormone therapy are common treatments used in prostate cancer. Chemotherapy drugs, such as docetaxel, target cancer...
Read MoreIn a nutshell The authors aimed to determine erectile dysfunction and incontinence issues in patients following prostate surgery. Some background Prostate surgery is a common treatment used in prostate cancer. It involves surgical removal of the prostate gland. There are numerous types of prostate surgery. Nerve-sparing surgery aims to remove the...
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In a nutshell This study examined the effect of maternal diabetes on diabetes in children. Some background Obesity in children can increase the risk of developing type 2 diabetes (T2D). However, other factors are also thought to increase this risk. Children with T2D generally have a parent with diabetes. The effect of maternal diabetes is greater...
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In a nutshell This study examined whether a mutation in the GLUL gene can increase the risk of mortality in patients with type 2 diabetes. Some background Coronary heart disease (CHD) is a thickening of the wall of the arteries located in the heart. This can lead to a reduction in the blood supply to the heart and, ultimately, a heart attack....
Read MoreIn a nutshell This paper studied how diet patterns affect the risk of coronary heart disease. Some background Coronary heart disease occurs when there is a build-up of substances like fat in the blood vessels. This increases the risk of heart attacks. Individual foods, such as red meat and saturated fats (fats found in...
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In a nutshell The authors assessed the role of amputation (removal) in the management of melanoma in limbs (arms or legs). Some background There are many treatment options available for patients with limb melanoma. Isolated limb perfusion (ILP) is one of the most common and effective treatments for limb melanoma. In ILP, high doses of chemotherapy...
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