In a nutshell This study examined whether depressive symptoms and stress have a negative impact on cardiovascular outcomes in patients with type 2 diabetes. The authors concluded that both depressive symptoms and stress increase the risk of worse cardiovascular outcomes in type 2 diabetes. Some background Cardiovascular disease (CVD) is the...
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In a nutshell This study aimed to determine the safety and efficacy of a combination of the anticancer drugs afatinib (Gilotrif) and nimotuzumab (Theraloc) to treat kinase inhibitor resistant EGFR-mutant-NSCLC. The study found that a combination of these drugs had encouraging potential and an acceptable safety profile. Some background A mutation...
Read MoreIn a nutshell This study looked at the potential benefit of introducing luteinizing hormone (LH) earlier during ovarian stimulation in older women. Starting LH on the earlier date was shown to increase clinical pregnancy rates. Some background There is an increased number of older women (over 35) seeking help to get pregnant. Success rates usually...
Read MoreIn a nutshell This study looked at vitamin D levels and pregnancy rates in patients undergoing in vitro fertilization (IVF). The study found that pregnancy rates were signficantly higher in the patients who had higher vitamin D levels. Some background Vitamin D is important for good health. The main source of vitamin D is from the action of...
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In a nutshell This study assessed the risks of rheumatoid arthritis (RA) patients developing chronic kidney disease (CKD) and glomerulonephritis (GN), and subsequently developing cardiovascular (CV) complications. The study concluded that there was an increased risk of CKD and GN in RA patients, and an increased risk of CV complications in patients...
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In a nutshell This trial assessed whether the anti-cancer drug crizotinib (Xalkori) leads to decreased kidney function as a side effect. The trial concluded that while taking crizotinib kidney function is decreased; however, function recovers once drug administration is stopped. Some background Several non-small cell lung ancers...
Read MoreIn a nutshell This study compared the safety and effectiveness of inhaled insulin with injected insulin. This study concluded that inhaled insulin was as effective as injected, with less incidence of very low blood glucose levels, but with higher incidence of cough. Some background Currently, the typical treatment for type 1 diabetes (T1D), and...
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In a nutshell This study looked at the association between physical activity after a diagnosis of breast cancer and breast cancer survival. The study concluded that excercise following diagnosis was associated with a decreased risk of death in breast cancer patients. Some background Greater physical activity has been linked with decreased risk of...
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In a nutshell This study assessed the safety and effectiveness of tocilizumab (TCZ, Actemra) in patients with systemic juvenile idiopathic arthritis (sJIA). The study concluded that TCZ was safe and effective. Some background Arthritis causes pain, stiffness, swelling and restricted movement in the joints. sJIA is a severe form of arthritis that...
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In a nutshell This study investigated which types of immune cells are more active in fighting colorectal cancer which has spread to the liver. It was found that T cells are the most active. Some background It is thought that the immune system response to colorectal cancer (CRC) is an important factor in determining whether the disease progresses...
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In a nutshell This long-term study examined the safety and effectiveness of botulinum toxin A (onabotulinumtoxinA, OnabotA, or Botox) in the treatment of urinary incontinence in patients with overactive bladders. Researchers concluded that OnabotA consistently improves urinary incontinence due to bladder muscle over-activity. Some background...
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In a nutshell This study examined the characteristics which could predict which patients with type 2 diabetes would most likely respond to bariatric surgery. The authors concluded that lower blood glucose levels prior to surgery and a shorter duration of diabetes could predict response to bariatric surgery. A combination of gastric plus diversion...
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