In a nutshell This review examined the safety and effectiveness of once weekly GLP-1 receptor agonists for the treatment of type 2 diabetes. The authors concluded that once weekly GLP-1 RA drugs are convenient, safe and effective for the treatment of type 2 diabetes. Some background Patients with type 2 diabetes (T2D) initially produce...
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In a nutshell This study compared the efficacy of antitumor drugs nivolumab (Opdivo) and docetaxel (Taxotere) in the treatment of advanced non-small-cell lung cancer (NSCLC). The study concluded that nivolumab has better activity in advanced nonsquamous NSCLC which express the ligand PD-L1 and has a safer toxicity profile overall than docetaxel. Some...
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In a nutshell The authors reviewed different treatment options for melanoma that spread to brain. This included surgery and combination treatment, among others, and scope for future treatments. Some background In advanced melanoma, the cancer often spreads to the brain. This is called brain metastasis. This affects quality of life and also...
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In a nutshell The authors aimed to analyze the safety and effectiveness of increasing doses of methotrexate (Trexall) in combination with adalimumab (Humira) in early rheumatoid arthritis (RA). The authors found out that increased doses of methotrexate resulted in improved outcome in RA. Some background In RA, the immune system begins...
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In a nutshell This study assessed whether subcutaneous (SC) methotrexate (MTX) was effective in rheumatoid arthritis (RA) patients who suffered side effects from oral MTX, or where oral MTX was ineffective. The study concluded that SC MTX injections were effective and very well tolerated. Some background RA is a chronic autoimmune disease (when...
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In a nutshell The authors evaluated the effect of a type of immunotherapy in treating advanced melanoma. This immunotherapy was found to be safe and effective. Some background In advanced melanoma (stage 3 or 4), the cancer spreads to the other parts of the body. This is called metastasis. Immunotherapy is a promising treatment option...
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In a nutshell This study investigated what can predict treatment success in men with benign prostatic hyperplasia (BPH). Researchers concluded that certain bladder characteristics, as identified by ultrasound, are reliable predictors of treatment success with alpha-blockers. Some background Men with BPH often experience bothersome urinary...
Read MoreIn a nutshell This phase 1 and 2 clinical trial recruiting in Lousiville, Kentucky will evaluate the safety of vemurafenib (Zelboraf) in combination with metformin (Glucophage) in advanced melanoma patients. The primary goal of phase 1 is to observe severe or life-threatening adverse events (grade 4) in 6 melanoma patients receiving vemurafenib with...
Read MoreIn a nutshell This study looked at risk factors associated with the prognosis of triple negative breast cancer patients who received neoadjuvant therapy. This study concluded that lymph node status after neoadjuvant therapy is the major prognostic factor for these patients. Some background Triple negative breast cancer (TNBC) is a type of cancer...
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In a nutshell The authors studied the effect of flaxseed on blood pressure. Patients taking flaxseed had a greater decrease in blood pressure than patients who did not. Some background Systolic blood pressure refers to the blood pressure when the heart contracts, while diastolic blood pressure refers to the blood pressure when the heart...
Read MoreIn a nutshell This study examined the effects of a low carbohydrate diet and a low fat diet on quality of life in patients with type 2 diabetes. The authors concluded that a low carbohydrate diet improves quality of life. Some background Obese patients and patients who have type 2 diabetes (T2D) have a lower quality of life compared to...
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In a nutshell This study examined whether sildenafil (Viagra) treatment increases insulin production and action in patients with prediabetes. The authors concluded that sildenafil treatment enhances insulin action. Some background Prediabetes is a condition in which blood glucose (sugar) levels are higher than normal but not high enough...
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