In a nutshell This study reviewed evidence on local treatments for erectile dysfunction. Researchers concluded that local treatment with alprostadil (Muse, Vitaros) is a safe and effective alternative treatment option for erectile dysfunction. Some background Drug therapy with phosphodiesterase-5 inhibitors (PDE5i), such...
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In a nutshell This study investigated the relationship between erectile dysfunction and cardiovascular risk, specifically plaque build-up in major arteries. Researchers concluded that men with erectile dysfunction are at increased risk of cardiovascular disease, and recommend increased screening. Some background Atherosclerosis (build-up of...
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In a nutshell This study examined the potential benefit of early intensive hormonal therapy (combined androgen blockade) in men with high-risk local prostate cancer, given before surgery. Researchers concluded that intensive hormone therapy may be more effective than standard treatment in reducing androgen levels, but seldom results in complete tumor...
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In a nutshell This study looked at the risk of developing contralateral breast cancer (CBC) in patients with or without BRCA mutations. The study concluded that age at the time of first cancer diagnosis is a strong risk factor for CBC in patients with BRCA. Some background Contralateral breast cancer (CBC) is the development of a second new breast...
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In a nutshell This study assessed the possible relationship between fertility drugs and cancer risk. The results showed a significant link between fertility drugs and thyroid cancer and melanomas, which requires further investigation. Some background Cancer is caused by abnormal cell growth. Fertility drugs, such as clomiphene citrate (Clomid),...
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In a nutshell This study examined the benefit of enzalutamide (Xtandi) in treating patients with advanced prostate cancer requiring chemotherapy. Researchers concluded that enzalutamide treatment results in delayed disease progression and increased overall survival. Some background Hormone therapy is commonly used to treat prostate cancer. By...
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In a nutshell The authors evaluated the risk factors for late spread of melanoma in patients disease-free for 10 to 15 years. Researchers concluded that age at time of diagnosis and tumor thickness are predictors of late melanoma relapse. Some background Early stage melanoma patients are often considered ‘cured’ after 10 or...
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In a nutshell This study investigated how oxaliplatin chemotherapy causes liver damage. The authors provided insight into the mechanism of liver injury, and suggest that bevacizumab (Avastin) may protect against such injury. Some background Oxaliplatin is a chemotherapeutic drug which is commonly used to treat advanced colorectal cancer (CRC)....
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In a nutshell This study investigated a possible link between dietary habits and strokes. The researchers found that stroke patients were less likely to maintain a healthy diet compared to healthy controls. Some background Healthy diet and physical activity have been shown to be beneficial for overall health, but have not been studied in detail...
Read MoreIn a nutshell This analysis examined whether contralateral prophylactic mastectomy is associated with improved survival and occurrence of contralateral breast cancer. The analysis concluded that CPM is associated with decreased occurrence of CBC but not improved survival among patients with increased genetic risk. Some background Women who are...
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In a nutshell The study investigated the effectiveness of a self-management program on antiemetic-induced constipation in breast cancer patients. The study concluded that the self-management program was effective for relieving the symptoms of constipation during chemotherapy. Some background Breast cancer patients may decide to take antiemetic...
Read MoreIn a nutshell This review examined the safety and effectiveness of technosphere insulin for the treatment of diabetes. The authors concluded that technosphere insulin is safe and effective in reducing blood glucose levels at meals. Some background Insulin (a hormone which reduces blood glucose levels) replacement therapy is used in the...
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