In a nutshell This study reported the effectiveness and safety of longer rituximab (Rituxan) maintenance therapy schedules (more than 2 years) for the treatment of patients with relapsed or refractory (r/r) indolent (painless) non-Hodgkin lymphoma (iNHL). The data showed that maintenance for up to 2 years with rituximab after response to...
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Comparing TURP and laser prostate surgery for benign prostatic hyperplasia in older patients and those with multiple medical conditions
In a nutshell This study compared the safety and effectiveness of transurethral resection of the prostate (TURP) and laser prostate surgery in older patients and those with multiple medical conditions. The data showed that compared to laser surgery, TURP had a lower risk of needing further surgery but higher complications rates in these...
Read MoreEvaluating the effectiveness and safety of ipatasertib plus abiraterone and prednisolone for the treatment of patients with metastatic castration-resistant prostate cancer.
In a nutshell This study evaluated the effectiveness and safety outcomes of ipatasertib (GDC-0068) in combination with abiraterone acetate (Zytiga) plus prednisone (Deltasone) (AAP) for the treatment of patients with previously untreated metastatic castration-resistant prostate cancer (mCRPC). The data showed that ipatasertib plus...
Read MoreEvaluating the effectiveness and safety of ciltacabtagene autoleucel for the treatment of patients with unresponsive multiple myeloma.
In a nutshell This study investigated the effectiveness and safety of ciltacabtagene autoleucel (cilta-cel), a chimeric antigen receptor (CAR) T-cell therapy for patients with previously treated relapsed or refractory (r/r) multiple myeloma (MM). The data showed that a single dose of cilta-cel was safe and effective for the treatment of these...
Read MoreEvaluating eribulin versus other treatment options in women with advanced breast cancer.
In a nutshell This study compared the safety and effectiveness between eribulin (Halaven) and non-eribulin-based chemotherapy regimens in patients with advanced breast cancer (BC). The data showed that eribulin significantly improved survival outcomes with manageable side effects in these patients. Some background Advanced BC has spread...
Read MoreEvaluating the effects of adding chemotherapy to trastuzumab treatment on mental functioning in older patients with HER2-positive breast cancer.
In a nutshell This study investigated the effects of adding chemotherapy to trastuzumab (Herceptin) treatment on cognitive (thinking and reasoning) functioning in older patients with HER2-positive (HER2+) breast cancer (BC). The data showed that the addition of chemotherapy did not impact cognitive functioning in these women. Some...
Read MoreTreating classic Hodgkin lymphoma in children – a guideline
In a nutshell These guidelines reviewed current recommendations on treating newly diagnosed classic Hodgkin lymphoma (cHL) in children and young adults, and cHL which has returned after previous treatment. Some background Hodgkin lymphoma is cancer of the lymph nodes, which are part of the immune system. It involves cancerous versions of B cells,...
Read MoreCan a vegan diet improve diabetes?
In a nutshell This review looked at whether a vegan diet can improve type 2 diabetes (T2D). It found that a vegan diet can lower glucose (sugar) levels for people with T2D. Some background Vegan diets have become more popular, for both health and ethical reasons. A vegan diet includes plant-based foods and avoids meat, eggs, or dairy. But can a vegan...
Read MoreDoes ICSI benefit couples where men have normal sperm quality?
In a nutshell This trial compared intracytoplasmic sperm injection (ICSI) to conventional in vitro fertilization (IVF) for couples where men have normal sperm quality. It found there was no clear benefit to ICSI over IVF for these couples. Some background IVF is an infertility treatment in which the woman’s ovaries are stimulated to produce...
Read MoreIs olokizumab a useful add-on treatment for rheumatoid arthritis?
In a nutshell This study looked at the safety and effectiveness of olokizumab (Artlegia) as an add-on to methotrexate (Otrexup) treatment in rheumatoid arthritis. It found the olokizumab was associated with significant improvements in RA symptoms and physical function. Some background Rheumatoid arthritis (RA) is a condition affecting...
Read MoreCan deep brain stimulation improve stomach problems in patients with Parkinson’s disease?
In a nutshell This study looked at the effectiveness of deep brain stimulation (DBS) in patients with Parkinson's disease (PD) and stomach problems. It found that DBS was associated with an improvement in stomach disorders and a reduced need for medication. Some background PD is a neurologic condition that can be difficult to treat as...
Read MoreDo eye injections reduce the risk of blindness in patients with severe diabetic eye disease?
In a nutshell This study looked at the use of aflibercept (Eylea) eye injections for the treatment of severe nonproliferative diabetic retinopathy (DR; diabetic eye disease). It found that more than half of the patients treated with aflibercept showed a significant improvement in DR after 6 months. Some background DR is one of...
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