In a nutshell This study aimed to compare enasidenib (Idhifa) to current standard of care therapies for patients with relapsed/refractory (r/r) acute myeloid leukemia (AML) and an isocitrate dehydrogenase 2 (IDH2) mutation who are ineligible for hematopoietic stem cell transplantation (HSCT). This study concluded that enasidenib significantly...
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In a nutshell This study evaluated the effect of brain metastases (BMs) status on immunotherapy effectiveness in patients with advanced lung cancer (LC). The data showed that the effectiveness of immunotherapy was similar in patients with or without BMs. Some background In 20-40% of patients with advanced LC, cancer spreads from the lung to the brain...
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In a nutshell This study compared the outcomes between radical prostatectomy (RP; prostate-removal surgery) and different types of radiotherapy (RT) in older patients with localized prostate cancer (PCa). The study found that RT offers similar cancer-specific outcomes to RP for low- to intermediate-risk patients. Some background...
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In a nutshell This study compared the effectiveness and safety of S-1 (tegafur/gimeracil/oteracil) and oxaliplatin (Eloxatin) combined with bevacizumab (Avastin) or with cetuximab (Erbitux) in patients with previously untreated advanced colorectal cancer with wild-type KRAS. This study concluded that the safety and effectiveness of...
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In a nutshell This study looked at the use of sacral neuromodulation (SNM) with the InterStim device in patients with overactive bladder (OAB). It found that SNM improved the symptoms of OAB over 3 years. Some background OAB is a condition in which the bladder contracts involuntarily leading to a sudden, urgent need to urinate....
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In a nutshell This study looked at the use of electrical stimulation (ES) for the treatment of stress urinary incontinence (SUI) in women. It found that ES improved incontinence-related quality of life over in the short-term. Some background SUI is a condition in which urine leaks out involuntarily when increased pressure is...
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In a nutshell This study investigated how people with myeloma responded to vaccines against COVID-19. It found that roughly half of the patients with multiple myeloma (MM) and most patients with other types of myeloma had protection against serious illness after the vaccine. The response to the vaccine was weaker for patients using certain treatments,...
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In a nutshell This study described the real-world effectiveness and safety of arsenic trioxide (ATO; Trisenox) combined with all-trans retinoic acid (ATRA; Vesanoid), without chemotherapy, in patients with newly diagnosed acute promyelocytic leukemia (APL). The authors concluded that a combination of ATO and ATRA showed good results for the...
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In a nutshell This study investigated the relationships among depression and anxiety, diet, and disease activity or physical function in patients with rheumatoid arthritis (RA). The data showed that there was a relationship between depression and lower fish intake frequency in these patients. Some background RA is a chronic inflammatory...
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In a nutshell This study reviewed the current minimally invasive surgical (MIS) approaches for the treatment of patients with rectal cancer (RC). Some background Rectal cancer (RC) is one of the most common types of cancer worldwide. RC involves the final part of the large intestine or rectum. RC can be treated by surgical removal of the tumor. Some...
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In a nutshell This study looked at the use of two types of stem cell transplant (SCT) in the treatment of T-cell lymphoma. It found that both haploidentical and umbilical cord blood SCT were good options for these patients. Some background T-cell lymphoma is a cancer affecting a certain type of blood cell called T-cells. T-cells are...
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In a nutshell This study assessed whether robot-assisted radical prostatectomy (RARP) improves lower urinary tract symptoms (LUTS) and quality of life (QoL) in patients with prostate cancer (PCa). The data showed an improvement in LUTS and QoL in patients with previously moderate or severe LUTS, 12 months after RARP. Some background PCa...
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