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Comparing the effectiveness and safety of nivolumab plus ipilimumab with chemotherapy versus pembrolizumab plus chemotherapy as first-Line treatment for metastatic NSCLC.

Comparing the effectiveness and safety of nivolumab plus ipilimumab with chemotherapy versus pembrolizumab plus chemotherapy as first-Line treatment for metastatic NSCLC.

Posted by on Oct 17, 2021 in Lung cancer | 0 comments

In a nutshell This study compared the effectiveness and safety outcomes of nivolumab (N; Opdivo) plus ipilimumab (I; Yervoy) with chemotherapy versus pembrolizumab (Pem; Keytruda) plus chemotherapy as first-line treatment in patients with metastatic non-small cell lung cancer (NSCLC). The data showed that N-I plus chemotherapy provided similar overall...

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How effective is the Altis® single-incision sling procedure for stress urinary incontinence in the long-term?

How effective is the Altis® single-incision sling procedure for stress urinary incontinence in the long-term?

Posted by on Oct 17, 2021 in Urinary incontinence | 0 comments

In a nutshell This study evaluated the long-term effectiveness and complication rates of the Altis® sling (Coloplast) use in women with predominant stress urinary incontinence (SUI). The data showed favorable results for long-term safety and effectiveness, and improved quality of life (QoL) in these patients. Some background SUI is a common...

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Do gliflozins or gliptins improve metabolic risk in patients with type 2 diabetes?

Do gliflozins or gliptins improve metabolic risk in patients with type 2 diabetes?

Posted by on Oct 17, 2021 in Diabetes mellitus | 0 comments

In a nutshell This study compared canagliflozin (Invokana) to teneligliptin (Teneria) for patients with type 2 diabetes (T2D). It found that canagliflozin led to greater improvement in body weight and metabolic outcomes in these patients. Some background T2D is a health condition of the metabolism. T2D prevents the body from responding well to the...

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Evaluating kidney and heart benefits of SGLT2 inhibitors for patients with diabetes and kidney disease

Evaluating kidney and heart benefits of SGLT2 inhibitors for patients with diabetes and kidney disease

Posted by on Oct 17, 2021 in Diabetes mellitus | 0 comments

In a nutshell This review looked at SGLT2 inhibitor medications for people with both type 2 diabetes (T2D) and chronic kidney disease (CKD). It found that SGLT2 inhibitors reduced worsening of the kidneys for these patients. Some background For people with diabetes, the body cannot control the amount of glucose (sugar) in the blood without treatment....

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Can pomalidomide improve multiple myeloma treatment?

Can pomalidomide improve multiple myeloma treatment?

Posted by on Oct 17, 2021 in Multiple Myeloma | 0 comments

In a nutshell This study looked at pomalidomide (Pomalyst) for patients with multiple myeloma (MM) which had returned after previous treatment. It found that adding pomalidomide to Vd (bortezomib, dexamethasone) led to better outcomes than Vd alone. Some background MM is a blood cancer in adults. Myeloma cells are cancerous versions of plasma cells,...

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How does all-trans retinoic acid and arsenic trioxide treatment affect the long-term quality of life of patients with acute promyelocytic leukemia?

How does all-trans retinoic acid and arsenic trioxide treatment affect the long-term quality of life of patients with acute promyelocytic leukemia?

Posted by on Oct 17, 2021 in Leukemia | 0 comments

In a nutshell This study assessed the treatment effects of all-trans retinoic acid (ATRA; Vesanoid) and arsenic trioxide (ATO; Trisenox), compared to ATRA with standard chemotherapy on long-term health-related quality of life (HRQoL) in patients with acute promyelocytic leukemia (APL). The data showed better long-term HRQoL measures in patients treated...

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Reviewing the chemotherapy-free treatment of follicular and marginal zone lymphoma

Reviewing the chemotherapy-free treatment of follicular and marginal zone lymphoma

Posted by on Oct 17, 2021 in Non-Hodgkin lymphoma | 0 comments

In a nutshell The review aimed to assess chemotherapy-free treatment of follicular lymphoma (FL) and marginal zone lymphoma (MZL).   Some background Standard therapy for slow-growing non-Hodgkin lymphoma (NHL) such as FL and MZL involves immunochemotherapy (ICT). ICT combines immunotherapy and chemotherapy treatments. However, many patients...

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Is pyrotinib effective as a second-line treatment in patients with HER2-positive breast cancer in a real-world setting?

Is pyrotinib effective as a second-line treatment in patients with HER2-positive breast cancer in a real-world setting?

Posted by on Oct 17, 2021 in Breast cancer | 0 comments

In a nutshell The authors evaluated the efficacy and safety of pyrotinib (Irene), for the treatment of HER2- positive metastatic breast cancer (MBC) in a real-world setting. The authors observed that pyrotinib was effective and well tolerated by patients.  Some background Breast cancer (BC) is the most common tumor in women...

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Reviewing focal therapies for patients with localized prostate cancer.

Reviewing focal therapies for patients with localized prostate cancer.

Posted by on Oct 16, 2021 in Prostate cancer | 0 comments

In a nutshell This article reviewed new studies on focal therapy (FT) in patients with localized prostate cancer (PCa), with a focus on treatment effectiveness.  Some background FT includes alternative, non-invasive methods for treating PCa. High-intensity focused ultrasound (HIFU) is a radiation-free technique that uses high-frequency ultrasound...

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How beneficial are foot-ankle flexibility and resistance exercises for preventing foot diabetic ulcer recurrence?

How beneficial are foot-ankle flexibility and resistance exercises for preventing foot diabetic ulcer recurrence?

Posted by on Oct 16, 2021 in Diabetes mellitus | 0 comments

In a nutshell This study assessed the effect of foot-ankle flexibility and resistance exercises in the prevention and recurrence of plantar foot-diabetic ulcers. The authors concluded that foot-ankle flexibility and resistance exercises can reduce the recurrence of plantar foot-diabetic ulcers and improve diabetic neuropathy (DN; nerve damage) and...

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Evaluating long-term safety and effectiveness of CT-P10 for the treatment of advanced follicular lymphoma

Evaluating long-term safety and effectiveness of CT-P10 for the treatment of advanced follicular lymphoma

Posted by on Oct 16, 2021 in Non-Hodgkin lymphoma | 0 comments

In a nutshell This study aims to investigate the long-term effectiveness and safety of the rituximab biosimilar CT-P10 (Truxima) in combination with cyclophosphamide (Cytoxan), vincristine (Oncovin), and prednisone (Deltasone) (CVP) compared with rituximab (Rituxan) for the treatment of advanced-stage follicular lymphoma (FL). The...

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Evaluating the effectiveness and safety of maintenance therapy with panitumumab plus fluorouracil and folinic acid in patients with RAS wild-type metastatic colorectal cancer.

Evaluating the effectiveness and safety of maintenance therapy with panitumumab plus fluorouracil and folinic acid in patients with RAS wild-type metastatic colorectal cancer.

Posted by on Oct 16, 2021 in Colorectal cancer | 0 comments

In a nutshell This study investigated the effectiveness and safety of panitumumab (Vectibix) when added to maintenance therapy with fluorouracil (Adrucil) and folinic acid (Leucovirin) (FU/FA) in patients with RAS wild-type metastatic colorectal cancer (mCRC). The data showed that maintenance therapy with FU/FA plus panitumumab was safe and...

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