In a nutshell This study evaluated the outcomes of immune and molecular targeted therapies after surgery for patients with stage III melanoma who did not undergo complete lymph node dissection. The data showed that the immune and targeted therapies after surgery were associated with increased survival without metastasis among these patients. Some...
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Evaluating the clinical outcomes in patients with relapsed or refractory classical Hodgkin lymphoma after first-line treatment.
In a nutshell This study evaluated the characteristics, treatment patterns, and outcomes of patients with relapsed or refractory (r/r) classical Hodgkin lymphoma (HL) after treatment with first-line therapy. Some background HL is a cancer of white blood cells. Most patients with HL respond to first-line chemotherapy regimens. However, up to...
Read MoreEvaluating the effectiveness and safety outcomes of second radiation therapy in patients with locally recurrent prostate cancer.
In a nutshell This study investigated the effectiveness and safety of re-irradiation for the treatment of patients with locally recurrent prostate cancer. The data showed that the use of re-irradiation in these patients was associated with good outcomes and low toxicity. Some background Radiotherapy (RT) is an effective treatment for localized...
Read MoreEvaluating treatment outcomes of hypofractionated stereotactic radiotherapy in patients with brain metastases.
In a nutshell This study investigated the optimal doses of hypofractionated stereotactic radiation therapy (HSRT) for patients with brain metastases (BM). The data showed that a HSRT dose of 30 Gy or higher delivered in 5 daily fractions was safe and effective in these patients. Some background Stereotactic radiosurgery (SRS) is commonly...
Read MoreEvaluating treatment outcomes of hypofractionated stereotactic radiotherapy in patients with brain metastases.
In a nutshell This study investigated the optimal doses of hypofractionated stereotactic radiation therapy (HSRT) for patients with brain metastases (BM). The data showed that a HSRT dose of 30 Gy or higher delivered in 5 daily fractions was safe and effective in these patients. Some background Stereotactic radiosurgery (SRS) is commonly used in...
Read MoreEvaluating treatment outcomes of hypofractionated stereotactic radiotherapy in patients with brain metastases.
In a nutshell This study investigated the optimal doses of hypofractionated stereotactic radiation therapy (HSRT) for patients with brain metastases (BM). The data showed that a HSRT dose of 30 Gy or higher delivered in 5 daily fractions was safe and effective in these patients. Some background Stereotactic radiosurgery (SRS) is commonly used in...
Read MoreEvaluating the effectiveness of extended robot-assisted prostate surgery and extended pelvic lymph node dissection in patients with very high-risk prostate cancer.
In a nutshell This study analyzed the effectiveness of extended robotic-assisted laparoscopic prostatectomy (eRALP) with extended pelvic lymph node dissection (ePLND) without any other additional treatments for patients with very-high-risk localized prostate cancer (PCa). The study found that eRALP with ePLND alone was safe and effective...
Read MoreEvaluating the effectiveness of EGFR-TKIs first-line treatment and performance status in older patients with EGFR-mutant NSCLC.
In a nutshell This study evaluated the effectiveness of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) first-line treatment and performance status in older patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The data showed that older patients with EGFR-mutated NSCLC who received EGFR-TKI first-line treatment with a...
Read MoreRecommendations for treatment-free remission in patients with chronic myeloid leukemia
In a nutshell The review aimed to develop recommendations for stopping tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia CML. Some background Tyrosine kinase inhibitors (TKI) are a type of targeted therapy. TKIs have improved the survival outcomes for patients with chronic myeloid...
Read MoreWhich type of CAR T cell therapy is best for patients with relapsed or refractory large B cell lymphoma?
In a nutshell The authors compared the safety and effectiveness of lisocabtagene maraleucel (liso-cel; Breyanzi) and axicabtagene ciloleucel (axi-cel; Yescarta) in patients with relapsed or refractory (r/r) large B cell lymphoma (LBCL). The study found that both treatments were similarly effective but liso-cel was better tolerated in these...
Read MoreCan urinary incontinence be treated with a combination of botox and bulking agent?
In a nutshell This study looked at the treatment of urinary incontinence (UI) with a combination of botulinum toxin (Botox) and polyacrylamide hydrogel (PAHG). This study showed that most patients achieved good UI control with this treatment. Some background UI (urine leakage) is a problem that affects many older women,...
Read MoreHow high should blood pressure be to reduce cardiovascular risks?
In a nutshell This study evaluated the optimal targets of blood pressure (BP) in older patients. It found that lowering systolic BP (SBP; BP when the heart beats) to 110-130 mmHg resulted in a lower risk of heart attack, stroke, or death compared to maintaining an SBP of 130-150 mmHg. Some background High blood pressure is a...
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