In a nutshell This study evaluated the effectiveness and safety of vagus nerve stimulation (VNS) for improving upper limb function in patients after ischemic stroke. The data showed that VNS was safe and improved upper limb function in these patients. Some background An ischemic stroke happens when blood flow through the blood vessels that supply...
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In a nutshell This study evaluated the effectiveness and safety of ropinirole (Requip) for the treatment of patients with Parkinson’s disease (PD). The data showed that ropinirole was effective in improving motor function and daily living of patients with PD but was associated with an increase in side effects. Some background Parkinson's...
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In a nutshell This study evaluated the effectiveness of immunotherapy in advanced lung cancer (LC) patients with and without brain metastases (BMs). The data showed that immunotherapy significantly improved overall survival in LC patients with and without BMs. Some background In 20-40% of patients with advanced LC, the cancer spreads from the lung to...
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In a nutshell This study evaluated the effectiveness of trilaciclib (Cosela) given before gemcitabine (Gemzar) plus capecitabine (Xeloda) (GC) chemotherapy regimen in patients with metastatic triple-negative breast cancer (mTNBC). The data showed that trilaciclib given before GC chemotherapy regimen was effective and significantly improved overall...
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In a nutshell This study identified clinical risk factors that resulted in the failure of dutasteride (Avodart) add-on treatment to alpha-adrenergic antagonists for patients with lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). The authors concluded that an intravesical prostatic protrusion (IPP; the enlargement of the...
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In a nutshell This study evaluated the effectiveness and safety of bevacizumab (Avastin) plus TAS-102 (Lonsurf; trifluridine-tipiracil) versus TAS-102 alone for the treatment of patients with metastatic colorectal cancer (mCRC). The data showed that bevacizumab combined with TAS-102 was effective with manageable side effects in improving the outcomes...
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In a nutshell This study evaluated the effects of physical therapies on improvement in psychosomatic symptoms and quality of life (QoL) in patients with breast cancer (BC) treated with aromatase inhibitors (AIs). The data showed that acupuncture can significantly reduce pain intensity and exercise training might improve QoL in these...
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In a nutshell This study evaluated which sequence of treatment should be given first, local or systemic (whole-body) treatment for patients with non-small cell lung cancer (NSCLC) and brain metastases (BMs). The data showed that systemic treatment followed by local treatment was associated with longer survival for patients with NSCLC and BM. Some...
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In a nutshell This study evaluated the safety and effectiveness of selinexor (Xpovio) in combination with carfilzomib (Kyprolis) and dexamethasone (Decadron) (XKd) in patients with relapsed/refractory (r/r) multiple myeloma (MM) that still responded to carfilzomib. The data showed that weekly administered XKd was highly effective and...
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In a nutshell This study compared the effectiveness of chiglitazar (Bilessglu) and sitagliptin (Januvia) on glycemic (blood glucose) variations, insulin resistance, and inflammation levels in patients with type 2 diabetes (T2D). The data showed that chiglitazar treatment was more effective at improving insulin resistance and inflammation compared...
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In a nutshell This study evaluated the effect of physical activity interventions on glycemic variability (GV; glucose levels variations) in patients with diabetes. The data showed that physical activity was associated with significantly reduced GV in these patients. Some background Physical activity has been shown to reduce hemoglobin A1c (the...
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In a nutshell The study aimed to investigate the effectiveness and safety of atezolizumab (Tecentriq) versus best supportive care after chemotherapy in patients with resected early-stage non-small-cell lung cancer (NSCLC). The study showed atezolizumab is effective and has better outcomes than best supportive in these...
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