In a nutshell This review evaluated the effectiveness of denosumab (Prolia) on bone mineral density (BMD) and joint destruction in patients with rheumatoid arthritis (RA). The authors concluded that denosumab treatment was linked to increased BMD and reduced joint destruction in patients with RA. Some background RA is a chronic inflammatory...
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In a nutshell This review evaluated the effect of prolonged fenofibrate (Tricor) treatment on the need for retinal laser treatment for diabetic eye disease in patients with type 2 diabetes (T2D). The data showed a reduced need for retinal laser treatment in these patients compared to placebo. Some background Diabetic eye disease refers to eye...
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In a nutshell This study evaluated the effectiveness and safety of ixazomib (Ninlaro)-dexamethasone (Decadron) (ixa-dex) versus pomalidomide (Pomalyst)-dexamethasone (pom-dex) combination for the treatment of patients with relapsed or refractory (r/r) multiple myeloma (MM). The data showed that ixa-dex was safe and as effective as pom-dex...
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In a nutshell This study compared the effectiveness and safety of avanafil (Stendra) with sildenafil (Viagra) for the treatment of patients with erectile dysfunction (ED). The data showed that avanafil had higher effectiveness compared to sildenafil in improving the symptoms of ED after 12 weeks. Some background Erectile dysfunction...
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In a nutshell This study compared the effectiveness and safety of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) and modified non-Hodgkin lymphoma (NHL) Berlin-Frankfurt-Münster-90 (NHL-BFM-90; cyclophosphamide, vincristine, ifosfamide, etoposide, adriamycin, methotrexate, vindesine, dexamethasone, cytarabine)...
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In a nutshell This study aimed to investigate the long-term safety and effectiveness of acalabrutinib (Calquence) with or without obinutuzumab (Gazyva) versus obinutuzumab with chlorambucil (Leukeran) in patients with chronic lymphocytic leukemia (CLL) that have never received treatment (treatment-naive). This study concluded that the...
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In a nutshell This study aimed to investigate the oncological effectiveness of intraoperative radiotherapy (IORT) and whole breast irradiation (WBI) for patients with early breast cancer (BC). This study concluded that there was a high oncological effectiveness for both groups of patients. Some background Intraoperative...
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In a nutshell This study evaluated the risk of developing secondary rectal cancer after radiotherapy (RT) in patients with prostate cancer. The data showed that RT significantly increased the risk of developing secondary rectal cancer in these patients. Some background Prostate cancer (PCa) is one of the most common form of cancer found in men. PCa...
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In a nutshell This study compared the effectiveness and safety of trastuzumab emtansine (T-DM1; Kadcyla) plus pertuzumab (Perjeta) versus taxanes plus trastuzumab (Herceptin) plus pertuzumab (THP) in patients with high-risk HER2-positive (+) early breast cancer (BC) after previous treatment with anthracycline-based chemotherapy. The data showed that...
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In a nutshell The study aimed to investigate optimized conformal (OC) total body irradiation (TBI) in pediatric patients with blood cancers who received further chemotherapy and allogeneic hematopoietic stem cell transplant (alloHSCT) with TCRαβ/CD19 depletion. This study concluded that OC-TBI is a...
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In a nutshell This study compared the risks of developing second primary cancers over time among survivors of non-Hodgkin lymphoma (NHL) versus the general population. The data showed that survivors of NHL had an increased risk of developing second primary cancers over time compared to the general population. Some background NHL is cancer that starts...
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In a nutshell This study evaluated the long-term effectiveness and safety of thulium laser enucleation of the prostate (ThuLEP) treatment for patients with benign prostatic hyperplasia (BPH). The data showed that ThuLEP treatment was safe and effective over the long term in these patients. Some background BPH is the non-cancerous increase in the size...
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