In a nutshell This study assessed the safety and effectiveness of oral, high-dose daily vitamin D3 for the prevention of diabetes in adults at high risk for type 2 diabetes (T2D). The authors concluded that oral, high-dose daily vitamin D3 at a dose of 4000 IU was safe and well-tolerated in patients with prediabetes that were overweight or...
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In a nutshell This study compared the effectiveness of common immuno-chemotherapy (ICT) treatments for advanced follicular lymphoma (FL) for front-line therapy. The study showed that obinutuzumab (Gazyva; G) combined with bendamustine (Treanda; Benda) (G-Benda-G regimen) had the best survival without cancer worsening in patients with advanced...
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In a nutshell This study aimed to investigate infusion reactions and the effectiveness of the combination of obinutuzumab (Gazyva) and chlorambucil (Leukeran) in patients with chronic lymphocytic leukemia (CLL). This study concluded that first dose infusion reactions with obinutuzumab can be reduced by using chlorambucil first and by using a very...
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In a nutshell This study assessed the link between metformin (Glucophage) use in hospitalized and non-hospitalized patients with diabetes and different outcomes due to coronavirus disease 2019 (COVID-19). The study showed that metformin use was associated with a protective effect in COVID-19 outcomes in patients with type 2 diabetes (T2D). Some...
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In a nutshell This study analyzed the impact of cognitive-motor dual-task training (CMDT) on patients with chronic stroke. The authors concluded that CMDT had beneficial effects on balance ability, gait, and upper limb function in patients with chronic stroke. Some background A stroke involves an interruption or slowing of blood flow and oxygen to the...
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In a nutshell This study evaluated the long-term relationship between bariatric surgery (BS; weight loss surgery) and major adverse cardiovascular events (MACE) in patients with obesity, diabetes, and hypertension (high blood pressure; BP). The study showed that a sustained decrease in MACE occurrence was associated with BS in...
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In a nutshell This study evaluated the long-term relationship between bariatric surgery (BS; weight loss surgery) and major adverse cardiovascular events (MACE) in patients with obesity, diabetes, and hypertension (high blood pressure; BP). The study showed that a sustained decrease in MACE occurrence was associated with BS in these patients. Some...
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In a nutshell This study evaluated the effectiveness and safety of an all-oral combination of ixazomib (Ninlaro), lenalidomide (Revlimid), and dexamethasone (Decadron) in transplant-eligible patients with newly diagnosed multiple myeloma (MM). The data showed that this combination was effective with manageable side effects in these...
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In a nutshell This study reported the long-term effectiveness and safety of adding carboplatin (Paraplatin) with or without veliparib (ABT-888) to standard chemotherapy given before surgery (neoadjuvant chemotherapy; NACT) in patients with early-stage triple-negative breast cancer (TNBC). The data showed that the addition of carboplatin to standard NACT...
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In a nutshell This study evaluated the effects of using regular acetaminophen (Paracetamol) on blood pressure (BP) in patients with hypertension (high BP). The data showed that regular daily acetaminophen use increased BP in these patients and increased the risk of cardiovascular disease when compared with placebo. Some background Hypertension or high...
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In a nutshell This study investigated the benefit of frequent surveillance imaging on the survival outcomes in patients with resected stage III melanoma. The data showed that patients who underwent less frequent imaging (12-monthly) had better outcomes than those who underwent more frequent imaging (3- to 4-monthly). Some background Melanoma is a...
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In a nutshell This study evaluated the effect of whole grain consumption in glycaemic (blood sugar) control of patients with diabetes. The data showed that whole grain consumption was beneficial for the control of blood glucose levels in these patients. Some background Diabetes is a condition in which patients have high blood sugar (glucose) levels...
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