In a nutshell The study aimed to evaluate the safety and effectiveness of an immunomodulatory IDO/PD-L1 targeting peptide vaccine (IO102/IO103) combined with nivolumab (Opdivo) in patients with metastatic melanoma (MM). The study concluded that the IO102/IO103 vaccine combined with nivolumab is safe and effective in these...
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In a nutshell This study evaluated the outcomes of patients with primary central nervous system lymphoma (PCNSL) on high-dose methotrexate (HD-MTX; Otrexup)-based chemotherapy followed by non-myeloablative consolidation therapy. The study showed that HD-MTX-based chemotherapy with non-myeloablative consolidation therapy is an alternative and...
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In a nutshell This study evaluated the effects of vitamin D supplementation on ovarian reserve markers in women with infertility due to reduced ovarian reserves and vitamin D deficiency. The study showed possible beneficial effects on ovarian reserve markers with vitamin D supplementation in these women. Some background Ovarian reserve refers to the...
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In a nutshell This study identified predictors of disease flare in patients with early, active rheumatoid arthritis (RA) that had stopped methotrexate (MTX; Otrexup) and/or abatacept (Orencia) treatment after clinical remission was achieved at 12 months. The data showed that patient function (HAQ-DI) and bone erosion based on magnetic resonance...
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In a nutshell The study evaluated the effectiveness and safety outcomes of adding abiraterone acetate (AA; Zytiga) and prednisolone (P; Deltasone) with or without enzalutamide (Xtandi) to androgen-deprivation therapy (ADT) in patients with high-risk non-metastatic prostate cancer (PC). The data showed that AAP added to ADT significantly improved survival...
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In a nutshell This study evaluated the benefits of a more versus a less intensive blood pressure (BP) lowering treatment strategy in patients with hypertension (high blood pressure). The data showed that a more intensive BP lowering treatment strategy significantly reduced the risks of stroke, heart failure, heart attacks, and cardiovascular death...
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In a nutshell This study evaluated the effectiveness of trimetazidine (Vastarel) versus other anti-anginal drugs for the treatment of patients with ischemic heart disease (IHD) who are not suitable for revascularization. The data showed that trimetazidine improved walking time and angina attacks in these patients. Some background Coronary artery...
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In a nutshell This study evaluated the long-term effectiveness and safety of device-aided therapies (DATs) for the treatment of real-world patients with advanced Parkinson’s disease (PD). The data showed that in the long-term, DATs are well maintained among these patients. Some background Parkinson's disease (PD) is a disorder in which part...
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In a nutshell This study evaluated the impact of mid-urethral sling (MUS) surgery and bulk injection (BI) therapy on sexual function in women with stress urinary incontinence (SUI). The study found that BI therapy and MUS surgery improved sexual function equally in sexually active women with SUI. Some background Stress urinary incontinence (SUI)...
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In a nutshell This study assessed the effects of canagliflozin (Invokana) therapy on body composition, glucose control, insulin resistance, and systemic (whole body) inflammation in patients with newly-diagnosed type 2 diabetes (T2D) compared to metformin (Glucophage). The data showed that canagliflozin therapy reduced visceral fat tissue, and...
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In a nutshell This study reviewed the effect of diabetes on lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The data suggested that LUTS were increased in patients with BPH that had diabetes compared to patients without diabetes. Some background Men above 50 years of age frequently experience LUTS due to benign...
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In a nutshell This study reviewed the effect of diabetes on lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The data suggested that LUTS were increased in patients with BPH that had diabetes compared to patients without diabetes. Some background Men above 50 years of age frequently experience LUTS due to...
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