In a nutshell This study evaluated the effectiveness and safety of adding venetoclax (Venclexta) to a dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) regimen as initial therapy in patients with aggressive B-cell lymphoma. The data showed that venetoclax with dose-adjusted EPOCH-R was effective...
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Evaluating the short-term functional outcomes and safety of holmium and thulium fiber laser enucleation of the prostate treatment for patients with benign prostatic hyperplasia.
In a nutshell This study evaluated the short-term functional outcomes and safety of holmium (HoLEP) and thulium fiber laser enucleation of the prostate (ThuFLEP) treatment for patients with benign prostatic hyperplasia (BPH). The data showed that both HoLEP and ThuFLEP surgeries are similar in terms of functional outcomes and safety in these patients....
Read MoreEvaluating the renin-angiotensin-aldosterone system inhibitors effects on mortality and disease severity in patients with COVID-19
In a nutshell This review analyzed the effect of renin-angiotensin-aldosterone system (RAAS) inhibitors including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on patient prognosis for COVID-19. The data suggested that there is no association between the use of ACEIs/ARBs and the risk of mortality and...
Read MoreA review of the effect of vitamin E supplementation in patients with rheumatoid arthritis.
In a nutshell This review evaluated the safety and effectiveness of vitamin E supplementation in patients with rheumatoid arthritis (RA). The authors concluded that regular supplementation with vitamin E can help to improve the overall quality of life (QoL) in patients by reducing joint discomfort, swelling due to excessive fluid buildup in tissues...
Read MoreEvaluating ponatinib treatment in any phase of treatment in patients with chronic myeloid leukemia resistant or intolerant to other tyrosine kinase inhibitors
In a nutshell This study aimed to investigate the safety and effectiveness of ponatinib (Iclusig) in patients with chronic myeloid leukemia (CML) who were resistant or intolerant to previous tyrosine kinase inhibitors (TKIs). This study concluded that ponatinib was effective in heavily pretreated patients when administered in any phase of...
Read MoreEvaluating the long-term outcomes of radiotherapy added to standard therapy for men with metastatic prostate cancer.
In a nutshell The study investigated whether radiotherapy (RT) addedd to standard of care (SOC) treatment would be beneficial for men with metastatic (spread) prostate cancer (mPC). The study showed that adding RT to SOC improved the survival of men with low burden (defined as fewer than 10 lesions, no greater than 3cm in diameter) mPC. Some...
Read MoreEvaluating the effectiveness of laser photocoagulation plus anti-VEGF treatment in patients with diabetic eye disease.
In a nutshell This study evaluated the effectiveness of panretinal photocoagulation (PRP) plus intravitreal anti-VEGF treatment versus PRP alone for the treatment of patients with diabetic retinopathy (DR; diabetic eye disease). The data showed that PRP with anti-VEGF combination treatment improved vision without an increase in side effects...
Read MoreEvaluating the long-term effectiveness of ibrutinib–rituximab treatment versus standard chemoimmunotherapy in patients with chronic lymphocytic leukemia.
In a nutshell This study investigated the long-term effectiveness of ibrutinib (Imbruvica)–rituximab (Rituxan) (IR) treatment versus standard chemoimmunotherapy (CIT) in patients aged 70 or younger with previously untreated chronic lymphocytic leukemia (CLL). The data showed that the IT regimen significantly improved the survival outcomes compared...
Read MoreEvaluating the effectiveness and safety of adding PolyPepI1018 peptide vaccine to maintenance therapy in patients with microsatellite stable metastatic colorectal cancer.
In a nutshell This study evaluated the effectiveness and safety of adding PolyPepI1018 peptide vaccine to fluoropyrimidine/bevacizumab (Avastin) maintenance therapy in patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). The data showed that PolyPEPI1018 added to maintenance therapy was safe and associated with specific...
Read MoreEvaluating treatment outcomes of fractionated stereotactic radiotherapy in patients with small and moderate-sized brain metastases.
In a nutshell This study investigated the effectiveness and safety of fractionated stereotactic radiation therapy (FSRT) for patients with small and moderate-sized brain metastases (BM). The data showed that FSRT was safe and effective in patients with BM of any size with excellent local control. Some background Stereotactic radiosurgery (SRS) is...
Read MoreEvaluating treatment outcomes of fractionated stereotactic radiotherapy in patients with small and moderate-sized brain metastases.
In a nutshell This study investigated the effectiveness and safety of fractionated stereotactic radiation therapy (FSRT) for patients with small and moderate-sized brain metastases (BM). The data showed that FSRT was safe and effective in patients with BM of any size with excellent local control. Some background Stereotactic radiosurgery (SRS) is...
Read MoreComparing the effectiveness and safety of percutaneous coronary intervention versus coronary artery bypass grafting in patients with left main coronary artery disease.
In a nutshell This study compared the effectiveness and safety of percutaneous coronary intervention (PCI) using drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) in patients with left main (LM) coronary artery disease (CAD). The data showed that both treatments were associated with a similar risk of heart attack, stroke, and death....
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