In a nutshell The study compared the effectiveness and safety of pertuzumab (Perjeta) and trastuzumab (Herceptin) combined therapy with trastuzumab alone in patients with HER2-positive (HER2+) advanced breast cancer (BC). The study found that the combined therapy was more effective and well tolerated compared to single therapy in...
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Comparing salvage and primary holmium laser enucleation of the prostate in patients with benign prostatic hyperplasia.
In a nutshell This study compared the safety and effectiveness of salvage (S) and primary (P) holmium laser enucleation of the prostate (HoLEP) in patients with benign prostatic hyperplasia (BPH). It also evaluated what were the procedures leading to S-HoLEP in these patients. The authors concluded that S-HoLEP was similar to...
Read MoreIs dorzagliatin an effective add-on treatment to metformin in patients with type 2 diabetes?
In a nutshell This study assessed the effectiveness and safety of adding dorzagliatin (HMS552) to metformin therapy in patients with type 2 diabetes (T2D) with inadequately controlled blood glucose (sugar) while using metformin (Glucophage) alone. The data showed effective blood glucose control, good tolerance, and safety in patients...
Read MoreEvaluating the safety and effectiveness of tebentafusp in previously treated patients with advanced uveal melanoma
In a nutshell The study evaluated the safety and effectiveness of tebentafusp (Kimmtrak) in patients with metastatic uveal melanoma who had received previous treatments. The study found that tebentafusp had promising effectiveness and a good safety profile in these patients. Some background Uveal melanoma is a rare and aggressive eye tumor....
Read MoreEvaluating the association between omega-3 polyunsaturated fatty acids dosage and blood pressure in patients with hypertension.
In a nutshell This study evaluated the association between omega-3 polyunsaturated fatty acids (PUFA) dosage (amount of drug administered) and blood pressure (BP) in patients with hypertension (high BP). The data showed that the optimal combined intake of omega-3 fatty acids for lowering BP is likely between 2 g/day and 3 g/day in these...
Read MoreEvaluating the effectiveness and safety of adebrelimab plus standard chemotherapy as first-line treatment for extensive-stage small cell lung cancer.
In a nutshell This study investigated the effectiveness and safety outcomes of adebrelimab (SHR-1316) plus carboplatin (Paraplatin) and etoposide (Etopophos)-based chemotherapy as first-line treatment for extensive-stage (ES) small-cell lung cancer (SCLC). The data showed that adebrelimab added to standard chemotherapy as first-line treatment...
Read MoreEvaluating the effectiveness of tadalafil alone, silodosin alone, and the combination of both in the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.
In a nutshell This study evaluated the effectiveness of tadalafil (Cialis) alone, silodosin (Rapaflo) alone, and the combination of both in the treatment of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The data showed that a combination of tadalafil plus silodosin is more effective than either drug alone in...
Read MoreA review of mRNA COVID-19 vaccines in patients with chronic lymphocytic leukemia
In a nutshell This review aimed to assess the strength of previous evidence and to better understand the current role of SARS-CoV-2 vaccination in patients with chronic lymphocytic leukemia (CLL). This review concluded that there is an overall lower seroconversion rate for SARS-CoV-2 vaccination in these patients as compared with the general...
Read MoreComparing the effectiveness and safety of prostate-only versus pelvic radiotherapy for patients with prostate cancer spread to nearby lymph nodes.
In a nutshell This study compared the safety and effectiveness of whole-pelvis radiotherapy (WPRT) and prostate-only radiotherapy (PORT) in patients with node-positive prostate cancer (PC) (PC that has spread to nearby lymph nodes). The study found that WPRT improves survival without relapse in these patients, with more short-term...
Read MoreHow safe and effective is dorzagliatin treatment in patients with type 2 diabetes?
In a nutshell This study evaluated the effectiveness and long-term safety of dorzagliatin in patients with type 2 diabetes (T2D) without previous antidiabetic treatment. The authors concluded that dorzagliatin blood glucose (sugar) levels with no serious side effects in these patients. Some background Glucokinase is a...
Read MoreIs the addition of low-dose prednisolone more beneficial than harmful to older patients with rheumatoid arthritis?
In a nutshell This study assessed the effectiveness and safety of daily administered prednisolone (Prelone) at a dose of 5 mg, as an add-on to the standard of care (SOC) in older patients with rheumatoid arthritis (RA). The authors concluded that low-dose prednisolone added to SOC had long-term benefits in these patients with a favorable balance of...
Read MoreCan walking speed be improved with foot-ankle therapeutic exercises in patients with diabetic nerve disease?
In a nutshell This study investigated the effects of foot-ankle therapeutic exercises on daily physical activity and gait (walking) speed in people with diabetic peripheral neuropathy (DPN). The data showed that at 12 weeks, these exercises led to improvements in fast walking speeds and quality of life compared to usual care. Some background...
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