In a nutshell This study evaluated the long-term effectiveness of fixed-duration treatment with venetoclax (Venclexta) plus rituximab (Rituxan) in patients with relapsed or refractory (r/r) chronic lymphocytic leukemia (CLL). The data showed that fixed-duration treatment with venetoclax plus rituximab was effective over the long term in these...
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Comparing the effects of different antidepressant therapies on depression symptoms in patients with Parkinson’s disease.
In a nutshell This study compared the effectiveness of different antidepressant therapies on depression in patients with Parkinson’s disease (PD). The data showed that escitalopram (Cipralex), pramipexole (Mirapex), and repetitive transcranial magnetic stimulation (rTMS) were more effective than routine treatment in these patients. After 4 weeks,...
Read MoreComparing the effects of a Mediterranean versus a low-fat diet in the secondary prevention of cardiovascular events in patients with coronary artery disease.
In a nutshell This study compared the effects of a Mediterranean versus a low-fat diet in the secondary prevention of major cardiovascular events (MACE) in patients with established coronary artery disease (CAD). The data showed that in secondary prevention, the Mediterranean diet was more effective in preventing MACEs compared to a low-fat diet in...
Read MoreEvaluating the effectiveness and safety of tiragolumab plus atezolizumab as a first-line treatment for patients with non-small cell lung cancer.
In a nutshell This study evaluated the effectiveness and safety outcomes of atezolizumab (Tecentriq) alone or with tiragolumab (MTIG7192A) as a first-line treatment for patients with non-small cell lung cancer (NSCLC). The data showed that tiragolumab plus atezolizumab significantly improved the objective response rate and the survival without...
Read MoreEvaluating the effects of olaparib plus abiraterone regarding patient-reported outcomes in patients with metastatic castration-resistant prostate cancer patients
In a nutshell This study compared the effects on patient-reported outcomes (PROs) of using olaparib (Lynparza) plus abiraterone (Zytiga) versus placebo plus abiraterone for the treatment of metastatic castration-resistant prostate cancer (mCRPC). The study found that adding olaparib to abiraterone in these patients did not...
Read MoreEvaluating the outcomes of single-pass versus multiple-pass during aquablation in patients with urinary symptoms due to benign prostatic hyperplasia.
In a nutshell This study evaluated the outcomes of single-pass versus multiple-pass during aquablation in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). The data showed that treatment with multiple passes during aquablation improved the urinary outcomes compared to a single pass in these patients. Some...
Read MoreComparing the effectiveness of using frozen versus fresh embryos in IVF
In a nutshell The study compared the effectiveness of transferring frozen embryos (FzE) versus fresh embryos (FrE) for couples with infertility using in vitro fertilization (IVF). The main finding of the study was that using FzE over FrE in IVF did not improve the chance of having a healthy baby. Some background IVF is one of the procedures that...
Read MoreComparing the effectiveness and safety of combined therapy of pertuzumab with trastuzumab versus single trastuzumab therapy in patients with HER2-positive advanced breast cancer
In a nutshell The study compared the effectiveness and safety of pertuzumab (Perjeta) and trastuzumab (Herceptin) combined therapy with trastuzumab alone in patients with HER2-positive (HER2+) advanced breast cancer (BC). The study found that the combined therapy was more effective and well tolerated compared to single therapy in...
Read MoreComparing salvage and primary holmium laser enucleation of the prostate in patients with benign prostatic hyperplasia.
In a nutshell This study compared the safety and effectiveness of salvage (S) and primary (P) holmium laser enucleation of the prostate (HoLEP) in patients with benign prostatic hyperplasia (BPH). It also evaluated what were the procedures leading to S-HoLEP in these patients. The authors concluded that S-HoLEP was similar to...
Read MoreIs dorzagliatin an effective add-on treatment to metformin in patients with type 2 diabetes?
In a nutshell This study assessed the effectiveness and safety of adding dorzagliatin (HMS552) to metformin therapy in patients with type 2 diabetes (T2D) with inadequately controlled blood glucose (sugar) while using metformin (Glucophage) alone. The data showed effective blood glucose control, good tolerance, and safety in patients...
Read MoreEvaluating the safety and effectiveness of tebentafusp in previously treated patients with advanced uveal melanoma
In a nutshell The study evaluated the safety and effectiveness of tebentafusp (Kimmtrak) in patients with metastatic uveal melanoma who had received previous treatments. The study found that tebentafusp had promising effectiveness and a good safety profile in these patients. Some background Uveal melanoma is a rare and aggressive eye tumor....
Read MoreEvaluating the association between omega-3 polyunsaturated fatty acids dosage and blood pressure in patients with hypertension.
In a nutshell This study evaluated the association between omega-3 polyunsaturated fatty acids (PUFA) dosage (amount of drug administered) and blood pressure (BP) in patients with hypertension (high BP). The data showed that the optimal combined intake of omega-3 fatty acids for lowering BP is likely between 2 g/day and 3 g/day in these...
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