In a nutshell The authors aimed to assess the effectiveness of prolonged hormone therapy to treat women with early breast cancer. Some background Tamoxifen (Nolvadex) is a type of hormone therapy used to treat breast cancer. It attaches to the estrogen receptors (surface structures that respond to estrogen hormone) present on some cancer cells...
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In a nutshell The authors aimed to assess the benefits of prolonged use of hormone therapy to treat breast cancer in women undergoing the menopause transition. Some background Endocrine or hormone therapy is a type of treatment used to fight cancer cells with the presence of hormone receptors (HR+). Hormones natural to our body such as estrogen or...
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In a nutshell The authors aimed to determine the long-term effects of hormone therapy to treat post-menopausal women with advanced breast cancer. Some background Hormone therapy is a form of breast cancer treatment. It targets cancer cells that may be affected by hormones. It is often administered prior to surgery in patients who are unfit to...
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In a nutshell The authors aimed to determine the effectiveness of exemestane (Aromasin) to treat premenopausal women with breast cancer and treatment outlook in comparison to tamoxifen (Nolvadex). Some background Tamoxifen is a type of hormone therapy used to treat breast cancer. This type of treatment is generally specific for hormone receptor...
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In a nutshell This paper evaluated the role of progesterone receptor in determining the outcome of cancer. Some background Estrogen receptor positive and human epidermal growth factor 2 (HER2) negative breast cancer refers to cancer that has estrogen receptors present on cancer cells and HER2 absent on cancer cells. Ki-67 is a protein that...
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In a nutshell This paper studied the impact of endocrine therapy on sexual function in postmenopausal patients with breast cancer. Some background Endocrine therapy is used in the treatment of hormone receptor positive early breast cancer. Hormone receptor positive breast cancer is cancer which has an abundant presence of the estrogen or...
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In a nutshell This paper studied the effect of aromatase inhibitors on cognitive function of older patients with breast cancer. Some background Aromatase inhibitors are drugs that block the activity of estrogen receptors (proteins on cells that react to the presence of the hormone estrogen). Not only do estrogen receptors promote cell growth...
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In a nutshell This clinical trial in New Jersey and Massachussetts (United States) aims to study anastrozole (ANAS, Arimidex) in treating aromatase inhibitor musculoskeletal symptoms in female patients with stage I-III breast cancer. The outcome to be measured is the stopping of treatment due to musculoskeletal symptoms and its association with the...
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In a nutshell This paper studies the ideal length of time needed for patients to receive letrozole (Femara) treatment to allow for breast conserving surgery. Some background Neoadjuvant chemotherapy (chemotherapy treatment given before primary treatment) compared with adjuvant chemotherapy (treatment given alongside...
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In a nutshell This study evaluated breast cancer risk and outcomes among postmenopausal women using hormone replacement therapy. Some background Progesterone and estrogen are steroid hormones that have a crucial role in female maturation and reproduction processes. The female menstrual cycle, ovulation and pregnancy are only part of the...
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In a nutshell This study examined whether a combination of hormonal therapy and therapeutic cancer vaccination is an effective treatment for patients with estrogen positive (ER+) metastatic breast cancer (cancer that has spread beyond the breast, to distant organs and tissues of the body). Some background Vaccines are used to prevent many diseases...
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In a nutshell This study investigated different scoring scales which could be used to determine the risk of recurrence among estrogen receptor-positive (ER+) breast cancer survivors. Some background Breast cancer survivors are at risk of developing distant recurrence of the cancer even many years after initial cancer treatments. Since usually...
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