In a nutshell This study examined whether a device could reduce chest pain in patients with coronary artery disease. Some background Coronary artery disease refers to a build-up of substance called plaque in the blood vessels to the heart. This narrows the blood vessel and blood flow is affected. Revascularization...
Read MoreIn a nutshell This paper studied whether a combination of ezetimibe (Zetia) plus statin treatment is beneficial to patients with acute coronary syndrome (disorders caused by reduced blood flow to the heart). Some background Statins are a group of drugs that reduce levels of low-density lipoprotein (LDL) cholesterol (fatty...
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In a nutshell This study examined the safety and effectiveness of the drug, vorapaxar (Zontivity), in reducing the risk of complications caused by atherosclerosis. Some background Atherosclerosis is the build-up of cholesterol, fat, and calcium as plaques in the walls of arteries. The plaques can rupture when there are sudden changes in...
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In a nutshell This study investigated whether alirocumab (Praluent) is effective and safe in treating patients with cardiovascular disease. Some background Cardiovascular disease includes a range of diseases that causes blood flow to the heart, brain or body to be reduced. Bad cholesterol (low-density lipoprotein (LDL) cholesterol) and fatty...
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In a nutshell This review analyzed the role of PCSK9 (protein convertase subtilisin/kexin type 9) in lipid (fat) metabolism and atherosclerosis, and therapeutic strategies targeting PCSK9. Some background PCSK9 is a protein which controls normal cholesterol uptake in the body, leading to high levels of low-density lipoprotein cholesterol...
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In a nutshell This study investigated whether higher doses of statins significantly improved cardiovascular outcomes compared to moderate or low doses. Some background Statins are a group of drugs used to lower cholesterol levels in the body. They notably reduce LDL-cholesterol levels, commonly referred to as the "bad" cholesterol....
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