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Looking for patients with relapsed or refractory follicular or diffuse large B-cell lymphoma to test a combination therapy containing polatuzumab vedotin antibody-drug conjugate

Looking for patients with relapsed or refractory follicular or diffuse large B-cell lymphoma to test a combination therapy containing polatuzumab vedotin antibody-drug conjugate

Posted by on Aug 21, 2017 in Non-Hodgkin lymphoma | 0 comments

In a nutshell This phase 2 clinical trial will test the safety and effectiveness of polatuzumab vedotin with obinutuzumab (Gazyva) and venetoclax (Venclexta) in patients with relapsed or refractory follicular lymphoma (FL) or rituximab (Rituxan) with polatuzumab vedotin and venetoclax in patients with relapsed or refractory diffuse large B-cell...

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Looking for patients with inflammatory breast cancer to test eribulin followed by chemotherapy

Looking for patients with inflammatory breast cancer to test eribulin followed by chemotherapy

Posted by on Jul 4, 2016 in Breast cancer | 0 comments

In a nutshell The main objective of this trial is to determine patient response to eribulin (Halaven) followed by doxorubicin (Adriamycin) and cyclophosphamide (Cytoxan) treatment. The main outcome to be measured is number of patients who experience a complete response to treatment (disappearance of signs of cancer). This trial is being conducted...

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Chemotherapy before surgery; is there a different in outcome between different types of breast cancer?

Chemotherapy before surgery; is there a different in outcome between different types of breast cancer?

Posted by on May 14, 2015 in Breast cancer | 0 comments

In a nutshell The authors aimed to evaluate if the outcomes of surgery following chemotherapy are different based on the focality of breast cancer tumors.  Some background Breast cancer can be characterised as 'unifocal', 'multifocal and 'multicentric'. This refers to the number of areas in which the cancer can be found...

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An analysis of TNF-blocking agents in combination with methotrexate for active rheumatoid arthritis

An analysis of TNF-blocking agents in combination with methotrexate for active rheumatoid arthritis

Posted by on Apr 13, 2014 in Rheumatoid Arthritis | 0 comments

In a nutshell This analysis investigated the benefits of combined methotrexate (MTX) and tumor necrosis factor (TNF) blockers in the treatment of active rheumatoid arthritis. Some background Rheumatoid arthritis (RA) is characterized by the improper activation of the immune system leading to chronic inflammation and joint damage. Active RA is...

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Can Zometa improve survival rate?

Can Zometa improve survival rate?

Posted by on Nov 4, 2013 in Breast cancer | 0 comments

In a nutshell This study investigated the influence of zoledronic acid (Zometa) on disseminated tumor cell (DTC) and survival of early stage breast cancer patients. Some background DTC are tumor cells that can be found in the bone marrow (the fatty and bloody tissue that fills the bone cavities and is the source of red blood cells and many white...

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A new treatment option for breast cancer

A new treatment option for breast cancer

Posted by on Sep 23, 2013 in Breast cancer | 1 comment

In a nutshell This phase II clinical trial examined the safety and efficacy of adding a drug called rh-endostatin (Endostar) to chemotherapy in breast cancer patients. Some background Cancer cells need blood supply in order to grow. As cancer grows, it forms its own blood vessels, a process called angiogenesis. Therefore, anti-angiogenesis...

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Evaluating the effect on survival of long-term hormone therapy in breast cancer patients

Evaluating the effect on survival of long-term hormone therapy in breast cancer patients

Posted by on Jul 30, 2013 in Breast cancer | 0 comments

In a nutshell This study examined the impact on survival of more than 5 years of adjuvant hormonal therapy in breast cancer patients. Some background Some types of breast cancer grow in response to female sex hormones (estrogen and progesterone) via their receptor (a protein found on breast cells). These are called hormone receptor-positive (HR+)...

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Low dose tamoxifen as post surgical treatment for ductal intraepithelial neoplasia

Posted by on Jul 28, 2013 in Breast cancer | 0 comments

In a nutshell This study investigated the use of low dose tamoxifen (nolvadex) on tumor recurrence when given as a post surgical treatment for ductal intraepithelial neoplasia. Some background Breast cancer cells which have not yet broken through the tissue layer in which they reside are often called intraepithelial, and are considered to be...

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Disease-free survival in breast cancer patients is increased by adding paclitaxel to FAC chemotherapy

Posted by on Jul 15, 2013 in Breast cancer | 0 comments

In a nutshell In this study researchers examined the effect of a specific chemotherapy combination on disease-free survival in patients with node negative breast cancer. FAC treatment was compared to FAC treatment plus paclitaxel (FACwP). Some background A combination of the drugs fluorouracil (efudex), doxorubicin (doxil), and cyclophosphamide...

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