In a nutshell This study investigated the long-term outcomes of patients with non-Hodgkin’s lymphoma (NHL) or multiple myeloma (MM) who received plerixafor (Mozobil) or placebo combined with G-CSF (granulocyte colony stimulating factor) before a stem cell transplant (SCT). This study concluded that adding plerixafor to G-CSF did not negatively...
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In a nutshell This study looks at how often patients being treated for non-Hodgkin lymphoma develop pneumonitis, a swelling of the lungs. The study concluded that patients being treated with R-CDOP chemotherapy are at the highest risk of developing pneumonitis. Some background Pneumonitis is a dangerous and potentially deadly swelling of the...
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In a nutshell This study aimed to investigate the outcome for patients aged over 60 who underwent reduced intensity allogeneic stem cell transplant. This study concluded that a subset of these patients will have extended survival and disease-free state following treatment. Some background Hematopoietic stem cell transplantation (HSCT) is increasingly...
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In a nutshell This study aimed to identify risk factors of recurrence after prostatectomy in high risk patients. Patients with more risk factors were more likely to experience disease recurrence at five years. Some background Prostatectomy is a treatment option for prostate cancer. The prostate tumor is surgically removed. There are several risk...
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In a nutshell This study reviewed evidence on the safety and effectiveness of stopping TKI therapy in patients with chronic myeloid leukemia (CML). Authors concluded that discontinuing TKI therapy is safe and effective in many patients with deep molecular response. Some background Tyrosine kinase inhibitors (TKIs) is a first-line treatment for...
Read MoreIn a nutshell This study examined how treatment with ibrutinib (Imbruvica), rituximab (Rituxan), and bendamustine (Treanda) impacts quality of life in chronic lymphocytic leukemia (CLL) patients. Factors such as fatigue, physical functioning, and well-being were all improved among those patients with the lowest scores before treatment. Some background...
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In a nutshell This study compared side effects between two similar therapies – nilotinib (Tasigna) and dasatinib (Sprycel) – for chronic myeloid leukemia (CML). Researchers reported more serious side effects with dasatinib than with nilotinib. Some background Tyrosine kinase inhibitor (TKI) therapy is a standard first-line treatment...
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In a nutshell This study looked at the effectiveness of chemotherapy followed by a single dose of radio-immunotherapy for treating patients with mantle cell lymphoma. The study concluded that radio-immunotherapy after standard chemotherapy is safe and effective to treat patients with mantle cell lymphoma. Some background Mantle cell lymphoma (MCL)...
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In a nutshell This study looked at the outcomes of patients with relapsed follicular lymphoma who were treated with allogeneic stem cell transplantation. The authors concluded that allogeneic stem cell transplantation is an effective treatment, and is most effective when treating earlier phases of the disease. Some background Follicular...
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In a nutshell This study examined outcomes in chronic myeloid leukemia (CML) patients with different types of a genetic abnormality known as BCR-ABL1. While patients with the BCR-ABL transcript e14a2 showed better response to treatment, long-term outcomes were similar between groups. Some background Certain genetic changes in CML can make it more...
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In a nutshell This study analyzed the outcomes of lymphoma and chronic lymphoblastic leukemia (CLL) patients who received haplo-cord stem cell transplantation. The study concluded that this method gives higher rates of engraftment and lower rates of graft-versus-host disease (GVHD) compared to haploidentical transplant. Some background High-risk...
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In a nutshell This study aimed to investigate if body mass index can impact outcomes of children with acute leukemia undergoing stem cell transplantation. This study concluded that being underweight at the time of transplant is associated with an increased risk of acute graft versus host disease in these patients. Some background Body mass...
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