In a nutshell This study aimed to investigate the effectiveness of venetoclax in chronic lymphocytic leukemia patients with 17p deletion. This study concluded that venetoclax is effective in this group of patients. Some background 17p deletion chronic lymphocytic leukemia (17p del CLL) is a type of CLL that has a poor prognosis.Venetoclax...
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Venetoclax for chronic lymphocytic leukemia patients with 17p deletion
In a nutshell This study aimed to investigate the effectiveness of venetoclax in chronic lymphocytic leukemia patients with 17p deletion. This study concluded that venetoclax is effective in this group of patients. Some background 17p deletion chronic lymphocytic leukemia (17p del CLL) is a type of CLL that has a poor prognosis.Venetoclax...
Read MoreIs thiotepa-based reduced-intensity conditioning effective before cord blood stem cell transplantation?
In a nutshell This study examined the effectiveness of thiotepa-based RIC in leukemia and lymphoma patients undergoing stem cell transplantation. The authors concluded that this treatment improved outcomes compared to standard RIC. Some background Before undergoing stem cell transplantation, patients with lymphoma or leukemia must undergo conditioning...
Read MoreSearching for patients with biochemical recurrence of prostate cancer
In a nutshell This trial is examining the effectiveness of Gallium-68 PSMA-11 PET imaging for determining the presence of metastatic prostate cancer. The main outcome to be measured is the detection of tumor location which will be confirmed by conventional follow-up. This study is being conducted in the UCSF Imaging Center in San...
Read MoreLenalidomide and blood clots: low risk in CLL and NHL
In a nutshell This study examined the risk of venous thromboembolism (VTE, a blood clot that forms in the veins of the legs, arms, or groin) in patients treated with lenalidomide (Revlimid). The study concluded that the risk of VTE was low with lenalidomide treatment. Some background Lenalidomide is an effective treatment already used in multiple...
Read MoreExercise, body composition and fatigue with androgen deprivation therapy
In a nutshell This study aimed to determine whether body composition (lean and fat mass) and exercise had an effect on fatigue levels in men treated with androgen deprivation therapy. The study concluded that fat mass was associated with fatigue, and an increase in lean mass due to exercise successfully reduced fatigue. Some background Androgen...
Read MoreNew treatment for children with chronic myeloid leukemia: Dasatinib
In a nutshell This study looked at the safety and effectiveness of dasatinib (Sprycel) to treat children with chronic myeloid leukemia in the chronic phase. The authors concluded that dasatinib is a safe and effective treatment. Some background There are few treatments for children (less than 18 years old) with chronic myeloid leukemia in the chronic...
Read MoreDoes a medication used to treat diabetes have anti-cancer potential?
In a nutshell This study looked at the anticancer effect of metformin (Glucophage), a drug commonly used to treat type 2 diabetes. The authors concluded that metformin in combination with current cancer therapies such as chemotherapy improved progression free survival in patients with advanced non-small-cell lung cancer. Some background Patients with...
Read MoreDoes a medication used to treat diabetes have anti-cancer potential?
In a nutshell This study looked at the anticancer effect of metformin (Glucophage), a drug commonly used to treat type 2 diabetes. The authors concluded that metformin in combination with current cancer therapies such as chemotherapy improved progression free survival in patients with advanced non-small-cell lung cancer. Some background Patients with...
Read MoreReviewing radiation therapy options for patients with relapsed or persistent DLBCL
In a nutshell This study reviewed several studies involving patients with relapsed or refractory (does not respond to treatment) diffuse large B-cell lymphoma (DLBCL) who received radiation therapy (RT). The authors concluded that RT can improve outcomes and disease control for patients with localized disease. Some background Diffuse large B-cell...
Read MoreWhich donor is best for transplant when a matched donor is not available?
In a nutshell This study aimed to investigate which type of donor is best for allogeneic stem cell transplant when a sibling matched donor is not available. This study concluded that both haploidentical (matched but not identical) and international donors can be used for allogeneic stem cell transplant when a sibling matched donor is not...
Read MoreSorafenib to improve outcome after transplant for patients with FLT3-ITD acute myeloid leukemia
In a nutshell This study aimed to evaluate the effect of sorafenib (Nexavar) on the outcomes of patients with acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 (FLT3)–internal tandem duplication (ITD) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study concluded that sorafenib before or after...
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