In a nutshell The present study evaluated the effect of Abiraterone acetate (AbAc) on survival and disease progression, when given to patients with metastatic prostate cancer (mPC) that is resistant to hormone therapy (castration-resistant). Some background Prostate cancer (PCa) growth is fueled by male hormones like...
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In a nutshell This paper presents the results of a clinical study which looked at the use of a new drug called Bosutinib (Bosulif) for the treatment of breast cancers diagnosed as being stage III or IV. In patients previously treated with chemotherapy, Bosutinib showed promising efficacy in delaying cancer progression. Some background Locally...
Read MoreIn a nutshell The present study evaluated the efficacy of a new drug, Regorafenib, for the treatment of refractory (progressing despite several lines of treatment) metastatic colorectal cancer (mCRC). Some background Many of the patients with colorectal cancer do not present any symptoms in the early stages of the disease so the cancer...
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In a nutshell This article presents the results from the first human trial of PD 0332991, a new anti-cancer drug. The main objective of the study was to determine the safety and recommended dose for further testing. Results warrant further studies and revealed that neutropenia (low white cell count) was the main side effect. Some background Cells...
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In a nutshell This report aimed to establish if radiofrequency ablation (RFA) of liver metastases originating from colorectal cancer (CRC) provides any benefits to patients with Stage IV of the disease. Main result: RFA extends progression-free survival by 7 months. Some background RFA is a medical procedure for treating patients with small tumors...
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In a nutshell The present study investigated if patients with spread colorectal cancer that have mutations in the KRAS gene benefit from Cetuximab treatment. Some background Cancer that originates in the colon or rectum (parts of the intestine) is called colorectal cancer (CRC). If the cancer has spread from its original location, beyond the...
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In a nutshell This article reports the results of recent studies involving the drug Docetaxel (Taxotere). The drug did not improve overall survival when added to androgen-deprivation therapy. Smaller doses given in shorter treatment cycles were found to be easier to tolerate and more effective. Some background Prostate cancer grows in...
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In a nutshell The present study compared the long-term efficacy and safety of different adjuvant chemotherapy regimens for breast cancer. Main results: chemotherapy clearly provides survival benefits; the higher the dosage, the higher the survival rates, despite more toxicity. Some background Many women with early stage breast cancer receive...
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In a nutshell The present study evaluated whether combining Bevacizumab (Avastin) with chemotherapy for patients with stage IV (metastatic) colorectal cancer (CRC) has any benefits in the terms of survival and quality of life. Main findings: Bevacizumab may be beneficial only as part of certain chemotherapy regimens. Some...
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mTOR – which stands for mammalian target of rapamycin – is a protein that regulates vital cell growth processes. mTOR receives external signals from growth factors, hormones, and proteins. It then gives the 'on' or 'off' signals for the cell to grow and divide, or nourish itself. If a cell's mTOR is not properly regulating...
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Regretfully, metastatic forms of prostate cancer (spread to distant sites via the blood system) treated with chemotherapy often acquire resistance to the drug, partially due to the repetitive nature of treatment. Resistance leads to tumor progression and treatment failure. This scientific article proposes a novel therapeutic target named WNT16B that...
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In a nutshell The present study summarized the outcomes of four clinical trials assessing the side-effects reported with sipuleucel-T treatment in patients with prostate cancer. The combined results indicated that this drug is relatively safe with mostly mild to moderate, short-term, and reversible side-effects. Some background As of...
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