In a nutshell The authors interpreted the results of a phase III trial on the use of enzalutamide (Xtandi) in treating patients with metastatic (cancer that has spread) hormone-resistant (castration-resistant) prostate cancer. Some background Hormone therapy is a common treatment used in prostate cancer. It targets the male sex hormones...
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Comparison of pembrolizumab with chemotherapy in ipilimumab-resistant melanoma
In a nutshell The authors compared the safety and effectiveness of pembrolizumab (Keytruda) to chemotherapy for the treatment of ipilimumab (Yervoy)-resistant melanoma. Some background Ipilimumab, an immunotherapy (treatment that uses the body’s own immune system to fight cancer), is an approved drug for the...
Read MoreHow the sites of tumors can affect prostate cancer patient survival
In a nutshell The authors determined the factors that predict cancer recurrence (return of cancer) and how they can affect overall survival in prostate cancer patients. Some background One of the most common treatments for prostate cancer is the surgical removal of the prostate gland (prostate surgery). However, 10% of patients who...
Read MoreNivolumab compared to chemotherapy in patients with advanced melanoma
In a nutshell The objective of this study was to evaluate the safety and effectiveness of nivolumab (Opdivo) as secondary treatment in advanced melanoma. Some background In the advanced stage of melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. BRAF inhibitors and immunotherapy are the standard treatments for...
Read MoreErlotinib with pemetrexed and cisplatin for lung cancer that has spread to the brain
In a nutshell The objective of this study was to evaluate the effect of erlotinib (Tarceva) in combination with pemetrexed (Alimta) and cisplatin (Platinol) in lung cancer that had spread into the brain (brain metastases). Some background Lung adenocarcinoma is the cancer of glandular cells of lungs. It is a common type of non-small cell lung...
Read MorePembrolizumab versus ipilimumab in advanced melanoma
In a nutshell The authors aimed to evaluate survival benefits of pembrolizumab (Keytruda) compared to ipilimumab (Yervoy) in advanced melanoma. Some background In the advanced stage of melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. One of the standard treatments for advanced melanoma is immunotherapy that uses...
Read MoreNew, upcoming treatment for hormone-resistant prostate cancer
In a nutshell The authors aimed to determine the effect of orteronel in patients resistant to hormone treatment. Some background Hormone therapy is commonly used in prostate cancer treatment and involves targeting the male sex hormones active in prostate cancer, such as testosterone. In some cases patients receiving hormone therapy may become...
Read MoreProteins can predict bone tumors and survival in hormone-resistant prostate cancer
In a nutshell The authors aimed to determine whether specific proteins can predict bone tumors and death in patients with hormone-resistant prostate cancer. Some background In advanced prostate cancer, tumors can spread out from the initial site of cancer to other parts of the body and bones, making treatment difficult. Hormone therapy...
Read MoreIpilimumab treatment improves survival in advanced skin cancer patients
In a nutshell The authors aimed to determine long-term survival in advanced skin cancer patients treated with ipilimumab. Some background Advanced melanoma is skin cancer that has spread deep within the skin to other sites of the body. There are limited treatments available for advanced skin cancer and patients have poor five-year survival...
Read MoreRadiation treatment and improved survival in prostate cancer patients
In a nutshell The authors aimed to determine the 10-year outcome in patients treated with brachytherapy for localized prostate cancer. Some background Localized prostate cancer is cancer that is confined within the prostate gland. It can often be treated with brachytherapy, a form of radiation that places radioactive seeds...
Read MoreNivolumab treatment for malignant skin cancer
In a nutshell The authors aimed to determine the effect of nivolumab in treating malignant skin cancer. Some background Nivolumab (Opdivo) is a man-made immune cell made to attack a specific disease that has been approved for treating malignant skin cancer (cancer that has spread throughout the body). Nivolumab functions by attaching to a...
Read MoreSalvage prostate surgery and factors affecting patient outcome
In a nutshell The authors aimed to determine patient outcome after salvage prostate surgery using patient information. Some background Prostate surgery is a common cancer treatment that involves surgically removing the prostate gland. Salvage prostate surgery is carried out after radiation therapy (involves directing a beam of radiation at the...
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