In a nutshell This trial evaluated the safety and effectiveness of the drug lapatinib (Tykerb) when used in combination with other chemotherapeutic drugs to treat women with metastatic HER2 positive breast cancer. This study concluded that lapatinib combined with vinorelbine or gemcitabine were effective in these...
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In a nutshell This trial examined the effectiveness of combining brachytherapy (a type of radiation) and chemotherapy for the treatment of locally recurrent non-small cell lung cancer (NSCLC) that has already been treated. The trial concluded that the combination of treatments was more effective than chemotherapy alone. Some background Locally...
Read MoreIn a nutshell This study examined the efficacy of including an anti-inflammatory hormone, prednisolone (Orapred), with the chemotherapy drug docetaxel (Taxotere) in the treatment of metastatic castration-resistant prostate cancer. The study concluded that prednisolone led to a decrease in specific adverse side effects of this type of...
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In a nutshell This study examined the effectiveness of palbociclib (Ibrance) in the treatment of hormone receptor-positive breast cancer patients. The authors found that palbociclib treatment increased progression free survival. Some background Major treatment options for hormone receptor-positive (HR+, dependent on the hormones estrogen and/or...
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In a nutshell This trial investigated the effectiveness and safety of a combination treatment for colorectal cancer resistant to chemotherapy. Some background Cancer evolves as it progresses in patients. Sometimes, this leads to resistance to treatment. In this case, the cancer is termed “refractory”. TAS-102 (Lonsurf) is a...
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In a nutshell This review discussed the use of nintedanib (Vargatef) in non-small cell lung cancer that has progressed despite treatment. Some background Non-small cell lung cancer (NSCLC) is often not diagnosed until the disease is advanced (spread to the lymph nodes or other areas of the body). Chemotherapy is the first-line treatment, but the...
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In a nutshell The authors aimed to determine the effectiveness and safety adding bevacizumab (Avastin) to a chemotherapy regimen in previously treated patients with metastatic (spread to other areas of the body) breast cancer. Some background Metastasis is the spread of cancer to other organs in the body. Patients with metastatic...
Read MoreIn a nutshell The authors determined the benefit of docetaxel (Taxotere) and prednisone (Deltasone) in treating metastatic (cancer that spreads) hormone-resistant prostate cancer. Some background Hormone therapy is a common treatment for prostate cancer. It targets the male sex hormones active in prostate cancer, such as testosterone. In...
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In a nutshell This study investigated the effect of erlotinib (Tarceva) with high dose celecoxib (Celebrex) in patients with advanced non-small cell lung cancer. Some background Some non-small cell lung cancers develop and grow due to a mutation (abnormality) in the epidermal growth factor receptor (EGFR) gene. EGFR tyrosine kinase inhibitors...
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In a nutshell This phase II trial based in Dallas, Texas aims to determine the effect of immunotherapy and stereotactic ablative body radiation as a metastatic hormone-resistant prostate cancer treatment. The main outcome to be investigated is time from treatment until cancer progression. The details Metastatic prostate cancer is cancer that...
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In a nutshell The authors evaluated the effect of dabrafenib (Tafinlar) in disease progression in melanoma patients with cancer that has spread to the brain (metastasis). Some background In advanced melanoma (stage III/IV) cancer spreads from the skin to other parts of the body, most commonly, to the brain. In...
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In a nutshell The authors reviewed the benefit of enzalutamide (Xtandi) in treating advanced hormone-resistant (castration-resistant) prostate cancer. Some background Hormone therapy is a common treatment used in prostate cancer. It targets the male sex hormones active in prostate cancer, such as testosterone. Some patients...
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