In a nutshell This paper studied the effects of daratumumab in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma. Daratumumab in combination with bortezomib and dexamethasone led to a longer survival period without worsening disease. Some background Multiple myeloma is a cancer of...
Read MoreIn a nutshell This study examined the effect of new treatments for patients who have relapsed after an autologous stem cell transplantation. The authors concluded that patients treated with new therapies, including brentuximab vedotin (Adcetris), have significantly better outcomes. Some background Hodgkin lymphoma (HL) is generally...
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In a nutshell This study examined the use of lymphocyte and monocyte blood counts to predict the outcome of autologous stem cell (immature blood cell) transplantation in children and young adults. The study concluded that the lymphocyte/monocyte ratio can be used to predict a likely relapse following autologous stem cell transplantation. Some...
Read MoreIn a nutshell The aim of this trial is to determine the effectiveness of a combination of the chemotherapies docetaxel (Taxotere) and carboplatin (Paraplatin) in advanced (spread beyond the prostate) prostate cancer. The main outcome to be measured is the number of patients who experience a decrease of 50% in prostate specific...
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In a nutshell This study examined the use of ibrutinib (Imbruvica) in patients with relapsed or refractory (did not respond to prior treatment) mantle cell lymphoma. The authors concluded that ibrutinib was a safe and effective treatment in these patients. Some background Mantle cell lymphoma is an aggressive form on non-Hodgkin lymphoma....
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In a nutshell This study examined the effectiveness of the combination bortezomib, rituximab, and dexamethasone (BORID) in patients with relapsed or refractory (did not respond to treatment) mantle cell lymphoma. This study concluded that this combination was effective and tolerable in these heavily pretreated patients. Some background Mantle cell...
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In a nutshell This study examined whether the chemotherapy combination CBV was safe and effective before stem cell transplantation in children with relapsed or refractory (did not respond to treatment) non-Hodgkin lymphoma. This study concluded that this option is safe and effective for many patients. Some background Outcomes for childhood...
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In a nutshell This study examined the effectiveness of bosutinib (Bosulif), a tyrosine kinase inhibitor (TKI), after previous treatment with multiple TKIs for chronic myeloid leukemia (CML). Researchers concluded that bosutinib was associated with good effectiveness for CML patients for whom previous TKIs have failed. Some background Targeted...
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In a nutshell This study examined remission rates with blinatumomab (Blincyto) treatment in patients with relapsed adult acute lymphoblastic leukemia (ALL). Researchers concluded that blinatumomab can achieve complete remission in patients with unfavorable ALL. However, this was an early-phase trial and more studies are needed. Some background...
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In a nutshell This study examined stem cell transplantation (SCT) in childhood acute myeloid leukemia (AML) patients who are not responding to other treatments. This study concluded that SCT was an effective treatment in many patients, but certain risk factors were associated with worse outcomes. Some background Between 5% and 23% of childhood AML...
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In a nutshell This study looked at the safety and effectiveness of donor stem cell transplantation in chronic lymphocytic leukemia (CLL) patients who have not responded well to previous treatments. The authors concluded that stem cell transplants can lead to long-term minimal residual disease-free survival for up to one-half of patients. Some...
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In a nutshell The authors aimed to determine guidelines for the treatment of relapsing, metastatic, and hormone-resistant prostate cancer. Some background Metastatic prostate cancer (advanced cancer) is cancer that has spread outside of the prostate to other organs of the body, despite treatment. Hormone therapy is the standard...
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