In a nutshell This study evaluated the association between preoperative lymphocyte to monocyte ratio and time to recurrence and overall survival in colon cancer. Some background Surgery is the principle treatment option for advanced non-metastatic (has not spread to distant organs) colon cancer. 5-fluorouracil-based chemotherapy is the...
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In a nutshell This study examined whether progression-free survival time could be used to predict long-term prognosis in non-resectable, locally advanced non-small cell lung cancer patients following chemotherapy and/or radiation therapy. Some background Non-small cell lung cancer is the most common form of lung cancer, and roughly 30% of tumors...
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In a nutshell This study compared polyp and adenoma miss rates from full-spectrum endoscopy colonoscopy with those of standard colonoscopy in colorectal cancer screening. Some background Colonoscopy is one of many tests used to screen for cancer or adenomas (precancerous growths) in the colon or rectum. Although colonoscopy is the...
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In a nutshell This review explored recent evidence regarding chemotherapy-induced peripheral neuropathy following treatment with different types of chemotherapeutic agents. Some background Chemotherapy, often used in the treatment of cancer, is well-known for its short-term toxic side-effects such as nausea or hair loss. However, symptoms of...
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In a nutshell This early phase study assessed the efficacy and safety of a new drug, Orteronel (TAK-700), in patients with castration-resistant prostate cancer. Some background Androgen deprivation therapy (ADT), or castration therapy, is the standard of care for advanced prostate cancer. ADT usually involves either surgical...
Read MoreIn a nutshell This review explored the use of insulin-like growth factor receptor blockers as treatment for castration-resistant prostate cancer. Some background Prostate cancer is dependent on androgens, male hormones such as testosterone, for growth. Therefore androgen deprivation therapy, which blocks the production or action of testosterone...
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In a nutshell This study examined tumor volume, tumor percentage and number of tumor foci as predictors of prognosis in prostate cancer. Some background Multiple variables are often used to predict prognosis among prostate cancer patients. These including PSA levels (prostate specific antigen; a protein produced by prostate cells whose levels rise...
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In a nutshell This study evaluated the use of multi-parametric magnetic resonance imagining (MRI) in the selection of prostate cancer patients for active surveillance. Some background Active surveillance was introduced as a therapeutic strategy to avoid overtreatment of cancer patients with a relatively non-threatening disease. In active...
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In a nutshell This study examined the different factors determining long-term survival following surgery for colorectal cancer. Some background Survival rates among colorectal cancer patients have increased substantially over the past 20 years. Early diagnosis, a deeper understanding of the disease and improvements in treatments and surgical...
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In a nutshell This article examined the use of a physical and psychosocial rehabilitation program to improve urinary dysfunction and patient quality of life following radiotherapy for the treatment of prostate cancer. Some background Advances in prostate cancer treatments, including radiotherapy and hormonal therapies, have significantly increased...
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In a nutshell This study investigated different scoring scales which could be used to determine the risk of recurrence among estrogen receptor-positive (ER+) breast cancer survivors. Some background Breast cancer survivors are at risk of developing distant recurrence of the cancer even many years after initial cancer treatments. Since usually...
Read MoreIn a nutshell This study investigated the patterns of cancer recurrence in non small-cell lung cancer (NSCLC) patients treated with stereotactic ablative radiotherapy (SABR). Some background Stereotactic ablative radiotherapy (SABR) is a method of treating early stage, small lung cancer tumors, that cannot be removed by surgery. Like all types of...
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