In a nutshell This study investigated how effective and safe radium 223 dichloride treatment was in patients with castration resistant prostate cancer (CRPC). It was concluded that radium 223 dichloride increased overall survival, reduced symptomatic skeletal events risk and was safe. Some background Treatment to decrease the male hormones,...
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In a nutshell The aim of this study was to determine whether the neutrophil to lymphocyte ratio (NLR) can be used to determine outcome in CRPC patients treated with enzalutamide (Xtandi). It was concluded that NLR could be used to predict the outcome for CRPC patients treated with enzalutamide. Some background Treatment for metastatic...
Read MoreIn a nutshell This study compared the effectiveness of ibrutinib (Imbruvica) and ofatumumab (Arzerra) in treating relapsed or persistent chronic lymphocytic leukemia (CLL). Researchers concluded that ibrutinib improved survival and disease progression more than ofatumumab. Some background Chemotherapy and immunotherapy are usually the first-line...
Read MoreIn a nutshell This phase 2 trial aims to evaluate the benefit of adding tremelimumab to durvalumab, two new types of immunotherapy, for metastatic castration-resistant prostate cancer. The main outcome to be investigated is treatment response. The trial is recruiting in several locations in Canada. The details Metastatic...
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In a nutshell The aim of this study was to examine whether combining radiation therapy and antiandrogen therapy improved survival in patients with prostate cancer that is not cured by initial treatment. It was concluded that the combination of radiation therapy and antiandrogen therapy improved survival when compared to radiation therapy...
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In a nutshell This phase 1/2 trial aims to test the safety and effectiveness of a combined treatment with the new vaccine LPV7 and TLR agonists in advanced melanoma patients after surgery. The main outcome to be measured will be the treatment toxicity and response of the tumors to the treatment. This trial is recruiting in Houston, Texas and...
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In a nutshell This study examined the healthcare usage of Hodgkin Lymphoma survivors. The authors concluded that survivors had increased healthcare usage up to 10 years after treatment. Some background Survivors of Hodgkin lymphoma (HL) sometimes experience late treatment effects. These include secondary lung cancer, secondary...
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In a nutshell This trial examined the effectiveness of bendamustine in patients with Hodgkin lymphoma that did not respond to treatment or returned after a period without disease. The authors found that this treatment was effective in this population. Some background About 30% of Hodgkin lymphoma patients will either not respond to treatment...
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In a nutshell This review outlines the treatment options for Hodgkin lymphoma that has relapsed or that did not respond to treatment. Some background Standard treatment for Hodgkin lymphoma is a combination of chemotherapy and radiation. More than 80% of patients achieve long-term cure with these treatments. Some patients do not respond to...
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In a nutshell This study summarized guidelines for the role of stem cell transplantation in patients with Hodgkin lymphoma. Some background While Hodgkin lymphoma is a curable disease in many, some patients experience a disease relapse or they do not respond to treatment. These patients are often treated with further chemotherapy followed by a...
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In a nutshell This study examined whether immunotherapy with sipuleucel-T (Provenge) shows a greater immune response if administered before or after androgen deprivation therapy (ADT). Authors present preliminary evidence of improved immune cell response when sipuleucel-T was administered first in patients with recurrent prostate cancer at high risk of...
Read MoreIn a nutshell This study examined the effects of androgen deprivation therapy (ADT) on cognitive function over 3 years. Researchers reported no significant differences in cognitive function following long-term ADT compared to control participants not undergoing ADT. Some background ADT is a type of hormone therapy commonly used to treat prostate...
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