In a nutshell This study investigated the effects of brentuximab vedotin in patients with relapsed/refractory Hodgkin lymphoma after stem cell transplant. Brentuximab vedotin appeared to be effective and safe for these patients. Some background Many patients with Hodgkin lymphoma (HL) are cured by standard therapies. However, some patients lose...
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Evaluating the effectiveness of stem cell transplant in patients with follicular lymphoma with early treatment failure
In a nutshell This study investigated the effectiveness of autologous stem cell transplantation (autoSCT) for patients with follicular lymphoma who experienced early treatment failure (ETF; relapse or disease progression within 2 years after first-line therapy). This study concluded that autoSCT may be an effective option for these patients. Some...
Read MoreEvaluating cabazitaxel in patients with metastatic castration-resistant prostate cancer
In a nutshell This study aimed to investigate the effectiveness of cabazitaxel used for patients with metastatic castration-resistant prostate cancer. This study found that patients treated with cabazitaxel had maintained or improved quality of life and pain control. Some background One treatment option for prostate cancer is androgen deprivation...
Read MoreEvaluating the long-term risk of cardiovascular mortality in lymphoma survivors
In a nutshell This study investigated the long-term risk of cardiovascular mortality (death due to heart and blood vessel disease) among lymphoma survivors, compared to the general population. This study concluded that lymphoma survivors have a higher cardiovascular mortality risk compared to the general population. Some background Advances in...
Read MoreSearching for patients with biochemical recurrence of prostate cancer
In a nutshell This trial is examining the effectiveness of Gallium-68 PSMA-11 PET imaging for determining the presence of metastatic prostate cancer. The main outcome to be measured is the detection of tumor location which will be confirmed by conventional follow-up. This study is being conducted in the UCSF Imaging Center in San...
Read MoreHow safe is long-term ibrutinib for chronic lymphocytic leukemia patients?
In a nutshell This study aimed to investigate the safety and effectiveness of ibrutinib (Imbruvica) in chronic lymphocytic leukemia. This study concluded that long-term administration of ibrutinib was well tolerated and provided effective disease control for most patients. Some background Ibrutinib is a targeted therapy that can be used for...
Read MoreWhat are the long-term outcomes following bendamustine treatment?
In a nutshell This study examined the long-term safety and effectiveness of bendamustine (Treanda) in lymphoma and leukemia. This study concluded that bendamustine is a safe and effective therapy for these patients. Some background Bendamustine has been shown to have high effectiveness and few side effects for a wide range of lymphomas. This drug is...
Read MorePredicting ischemic heart disease and stroke in survivors of childhood cancer
In a nutshell This study investigated the individual risk of ischemic heart disease and stroke through age 50 in 5-year survivors of childhood cancer. The authors concluded that these conditions can be reasonably predicted using information available after childhood cancer therapy. Some background For the 400,000 childhood cancer survivors in the...
Read MorePredicting ischemic heart disease and stroke in survivors of childhood cancer
In a nutshell This study investigated the individual risk of ischemic heart disease and stroke through age 50 in 5-year survivors of childhood cancer. The authors concluded that these conditions can be reasonably predicted using information available after childhood cancer therapy. Some background For the 400,000 childhood cancer survivors in the...
Read MoreComparing treatment regimens in patients with relapsed or refractory acute myeloid leukemia
In a nutshell This study aimed to compare myeloablative transplant and a sequential approach treatment in patients with relapsed or refractory acute myeloid leukemia. This study concluded that both treatments had similar outcomes for these patients. Some background Allogeneic hematopoietic stem cell transplantation (HSCT) is the only...
Read MoreSalvage chemotherapy options for relapsed/refractory acute myeloid leukemia
In a nutshell This study aimed to compare two salvage chemotherapy regimens for relapsed/refractory acute myeloid leukemia. This study concluded that there were no significant differences between the two regimens apart from cost. Some background Salvage chemotherapy is used to treat cancers that do not respond to other treatments. Relapsed...
Read MoreCan Genetic Profiling in Myeloma Determine Treatment Strategies?
Video Information Dr. Faith Davies, from the UAMS Myeloma Institute, and Dr. Brian Walker, from the University of Arkansas for Medical Sciences, share how tests showing abnormalities in gene expression can help classify myeloma patients, and how this information can help improve care for myeloma patients. Transcript Dr. Davies: I think there...
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