In a nutshell This study aimed to investigate if pretreatment with methylprednisolone would reduce infusion-related reactions associated with obinutuzumab use in patients with chronic lymphocytic leukemia. This study concluded that premedication with methylprednisolone reduces infusion-related reactions...
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In a nutshell This study examined if international prognostic scores (IPS) could help predict treatment outcomes for patients with advanced Hodgkin's lymphoma (HL). The authors found that the IPS system is losing its predictability as treatment strategies improve for these patients. Some background Patients with HL need to be treated...
Read MoreIn a nutshell This study aimed to investigate the effects of valproate (Depakene) and all-trans retinoic acid (ATRA) in treatment-naive elderly patients with acute myeloid leukemia. This study concluded that the addition of ATRA to decitabine (Dacogen) chemotherapy led to a higher remission rate and survival...
Read MoreIn a nutshell This study aimed to investigate if fertility preservation in patients with invasive breast cancer would affect disease-free survival. This study concluded that fertility preservation appears unlikely to affect disease-free survival in these patients. Some background Fertility preservation (FP) is the process of saving or...
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In a nutshell This study examined whether it is safe to switch from intravenous to subcutaneous rituximab (Rituxan) during first-line treatment of non-Hodgkin's lymphoma (NHL). The authors concluded that subcutaneous rituximab was safe and effective, and improved quality of life for patients. Some background Rituximab is a standard...
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In a nutshell This study examined if intensive chemotherapy after initial chemotherapy made treatment more effective for patients with multiple myeloma (MM). The authors concluded that intensive chemotherapy increased survival without tumor growth or spread for these patients. Some background In MM, cancer cells become different...
Read MoreIn a nutshell This study aimed to investigate the combination of ibrutinib with fludarabine, cyclophosphamide, and rituximab (FCR) as a frontline treatment in young, fit patients with chronic lymphocytic leukemia. This study concluded that this combination is promising as a...
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In a nutshell This study investigated the effectiveness of panitumumab (Vectibix) in the treatment of advanced colorectal cancer (CRC). Researchers suggested that this drug improved tumor response to the therapy. Some background CRC is one of the most common cancer worldwide. Chemotherapy such as FOLFOXIRI (leucovorin, fluorouracil, oxaliplatin,...
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In a nutshell This study assessed the safety and effectiveness of RVD (lenalidomide, bortezomib, dexamethasone) in patients with multiple myeloma before a stem cell transplant (SCT) in a real-life setting (outside of clinical trials). This study concluded that this treatment was safe and effective for these patients. Some background Multiple myeloma...
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In a nutshell This study evaluated whether FDG-PET/CT imaging during treatment helped predict outcomes for patients with diffuse large B-cell lymphoma (DLBCL). The authors concluded that mid-treatment imaging might help determine disease status rather than guide treatment decisions. Some background DLBCL is the most common type of...
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In a nutshell This trial is examining the most beneficial dose of an experimental AE37 vaccine when used with biological therapy pembrolizumab (Keytruda). The main outcomes to be measured are the maximum safest dose of AE37 and objective response rate. This study is recruiting in Illinois and West Virginia, US. The details Triple-negative...
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In a nutshell This study evaluated the safety and effectiveness of total lymphoid irradiation and anti-thymocyte globulin (TLI-ATG) conditioning before stem cell transplantation (SCT) in patients with lymphoma or leukemia. This study concluded that this regimen was well-tolerated and effective, especially for patients who had multiple lines of prior...
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