In a nutshell The authors aimed to determine whether or not the breast cancer treatment trastuzumab (Herceptin) increased the risk of developing certain infections. Some background Human epidermal growth factor receptor positive (HER2+) breast cancers are dependent on the HER2 protein for growth. It is often targeted with a particular...
Read MoreIn a nutshell This phase III trial aims to determine the effects of hypo-fractionated radiation compared to standard radiation therapy. The main outcome to be investigated is whether hypo-fractionated radiation has similar or better results when compared to standard radiation. This trial is recruiting in in Illinois, Oklahoma and Virginia, in the...
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In a nutshell The authors determined the factors that affected survival in prostate cancer patients with bone tumors when treated with zoledronic acid (Zometa, INN, Reclast). Some background Hormone therapy is commonly used to treat prostate cancer. It involves targeting the male sex hormones active in prostate cancer, such as...
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In a nutshell The authors analyzed the occurrence of treatment-related side effects in rheumatoid arthritis (RA) and the factors that cause discontinuation of such treatments. Some background In RA, high levels of immune system proteins are generated. This causes inflammation, leading to chronic pain. Disease-modifying...
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In a nutshell This study looked at the survival of patients with advanced rectal cancer when treated with chemotherapy either before or after chemoradiation and surgery. Some background A common treatment option for rectal cancer is a combination of chemotherapy and radiation therapy (chemoradiation) followed by surgery. Further...
Read MoreIn a nutshell The authors compared the effectiveness and safety of SB4, a biological variant of etanercept (Enbrel), to etanercept alone in patients with rheumatoid arthritis (RA). Some background In RA, high levels of immune system protein are generated, which causes inflammation. This can lead to...
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In a nutshell The authors determined whether hormone therapy had a negative impact on mental function (cognitive performance) in prostate cancer patients. Some background Hormone therapy is a common treatment used in prostate cancer. It targets the male sex hormones involved in prostate cancer, such as testosterone. Some studies have...
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In a nutshell The authors reviewed the biology as well as current and future treatment options for eye melanoma. Some background Uveal melanoma is a rare cancer (melanoma) of the eye. It involves three parts of the eye (iris, ciliary body and choroid) known together as the uvea. Eye melanoma is associated with a high risk...
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In a nutshell The authors determined whether hormone therapy increased the risk of diabetes in localized (confined to the prostate) prostate cancer. Some background Hormone therapy is a common treatment in prostate cancer. It targets the male sex hormones active in prostate cancer, such as testosterone. Further studies are required to...
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In a nutshell The authors aimed to determine whether severe skin and nail infections observed in patients with breast cancer were due to a combination-chemotherapy treatment. Some background Trastuzumab (Herceptin) is a common drug used to treat patients with human epidermal growth factor 2 positive (HER2+) breast cancer. The HER2 protein can...
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In a nutshell The authors evaluated the factors associated with improved outcomes in patients with lung cancer treated with stereotactic body radiotherapy (SBRT). Some background Stereotactic body radiotherapy (SBRT) is a type of radiotherapy used to treat lung cancer. With SBRT, a beam of radiation is focused directly on the tumor,...
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In a nutshell The authors determined the risk factors that led to disease reclassification (change in grade/status of the disease) in prostate cancer patients under active surveillance. Some background Active surveillance is common in early-stage prostate cancer management. It involves active monitoring of patients for any changes in symptoms or...
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