In a nutshell This study examined the safety and effectiveness of BEACOPP chemotherapy combined with ABVD chemotherapy in patients with early unfavorable Hodgkin lymphoma. This study concluded that the combination of the two chemotherapies was more effective than ABVD alone. The combination increased the rate of negative side effects. Some background...
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In a nutshell This study examined the incidence of metastatic disease (cancer that spreads) progression in men undergoing active surveillance. Authors concluded that active surveillance is an appropriate management of selected patients with low- to intermediate-risk prostate cancer. Only 3.1% of men progressed over an average follow-up of 6.4...
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In a nutshell This study investigated the outcomes of lower third rectal cancer patients treated with chemotherapy and radiation therapy (CRT). Researchers suggested that CRT could be beneficial for lower rectal cancer patients. Some background The most adequate treatment for lower rectal cancer is still a challenge. Prior studies suggested...
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In a nutshell This study developed guidelines for the early detection and treatment of hypophysitis (HP; inflammation of the pituitary gland), a side effect of treatment with ipilimumab. Researchers suggested that these guidelines are necessary to ensure early detection and treatment of this condition to prevent associated mortality. Some background...
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In a nutshell This study investigated the risk factors for venous thromboembolism (VTE; a blood clot in a vein) after hospital discharge following colorectal surgery. Researchers suggested that the length of hospitalization after surgery is associated with post-discharge VTE. Some background It is estimated that 31% of hospitalized patients are at...
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In a nutshell This study investigated the safe margin (the tissue removed around the tumor during surgery) for stage 2 melanomas (tumors with 1-2 mm in thickness). Researchers suggested that the safe margin during melanoma surgery is between 8 and 16 mm. Some background The standard treatment for patients with stage 2 melanomas (tumor...
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In a nutshell This study investigated the benefits of pre-surgery chemotherapy and radiation therapy (CRT) in patients with rectal cancer and pelvic lymph node metastasis (spread of cancer). Researchers suggested that CRT may have a beneficial impact in the disease outcomes of these patients. Some background CRT followed by surgery is the...
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In a nutshell This study investigated the effectiveness and safety of the chemotherapy XELOX combined with cetuximab (Erbitux) as treatment for metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that this combination was effective in these patients with manageable side effects. Some background Colorectal...
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In a nutshell The authors aimed to determine the effect of different treatments on the risk of developing invasive breast cancer (IBC) in women diagnosed with ductal carcinoma in situ (DCIS). The authors concluded that there was an interaction between age and follow-up period on IBC risk and that the benefit of radiation seemed to be smaller among...
Read MoreIn a nutshell This study investigated the outcomes of localized surgery following chemotherapy and radiation therapy (CRT) in rectal cancer. Researchers suggested that localized surgery should only be considered after a complete response to CRT. Some background Radical surgery or total mesorectal excision (TME; bowel and lymph nodes around...
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In a nutshell This study compared the effectiveness of different treatment options available for localized prostate cancer. Authors reported low rates of prostate cancer-specific mortality across all treatment groups. However, surgery and radiation therapy were associated with a lower rate of disease progression and metastases compared to active...
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In a nutshell This study investigated the impact of tumor budding (when surrounding the tumor there are tumor cells released from the main tumor that can spread to other places in the body) in colorectal cancer. Researchers suggested that tumor budding is predictive of lymph node metastasis (spread to the lymph nodes), recurrence (when the cancer comes...
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