In a nutshell This study analyzed the results of multiple studies to examine the effect of bortezomib (Velcade) on cardiac risk (heart health) in multiple myeloma. Results showed no effect on cardiac risk with bortezomib-based treatment. The incidence of cardiac events was low across all treatment groups. Some background Many multiple myeloma...
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In a nutshell This study examined two types of treatment regimes involving imatinib (Gleevac) for chronic myeloid leukemia (CML). Patients receiving reduced-intensity chemotherapy and a stem cell transplant before imatinib had similar outcomes to patients treated with imatinib alone. Some background Targeted therapy has become the standard...
Read MoreIn a nutshell The authors looked at the long-term outcomes for patients with advanced follicular lymphoma when treated with fludaranine, cyclophosphamide, and mitoxantrone (FCM). The authors concluded that FCM leads to long-lasting response with low rates of negative effects. Some background Follicular lymphoma (FL) is effectively treated with...
Read MoreIn a nutshell This study investigated the effectiveness of talimogene laherparepvec (Imlygic; T-VEC) with ipilimumab (Yervoy) in the treatment of inoperable stage 3 or 4 melanoma. Researchers concluded that this combination improves melanoma outcomes, with manageable side effects. Some background Immunotherapy has become an...
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In a nutshell This study examined the effectiveness of different doses of nilotinib (Tasigna) in patients with newly diagnosed chronic myeloid leukemia in chronic phase. This study concluded that nilotinib was safe and effective in treating chronic myeloid leukemia. Some background Chronic myeloid leukemia is a cancer where the...
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In a nutshell This study examined the outcomes of haploidentical stem cell transplantation (haplo-SCT) in adults with high-risk acute lymphoblastic leukemia (ALL). Researchers reported favorable outcomes with haplo-SCT for patients in the early stage of their disease. Some background ALL is a type of cancer in which the bone marrow makes too...
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In a nutshell This study examined the effectiveness of an increased dose of idarubicin (Idamycin) during the consolidation phase of treatment for acute myeloid leukemia (AML). This study concluded that an increased dose of idarubicin was associated with improved leukemia-free survival, without increased side effects. Some background Anthracyclines...
Read MoreIn a nutshell This study aimed to investigate the outcomes and side effects of radical prostatectomy, external beam radiation therapy, and active surveillance in men with localized prostate cancer. This study concluded that radical prostatectomy led to a greater decrease in sexual function and urinary continence compared to the other two treatment...
Read MoreIn a nutshell This paper compared ponatinib (Iclusib) and stem cell transplantation in leukemia patients with an abnormality on the T315I gene. Patients with acute lymphoblastic leukaemia (ALL) positive for the Philadelphia chromosome and patients with chronic myeloid leukaemia (CML) were studied. Authors reported improved survival with...
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In a nutshell This study examined the use of the combination of bendamustine (Treanda) and rituximab (Rituxan) as a firstline treatment in patients with follicular or mantle cell lymphoma. This study concluded that this treatment combination was more effective than the standard treatment of rituximab plus CHOP chemotherapy. Some background The...
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In a nutshell This paper studied the use of pioglitazone (Actos) with imatinib (Gleevec) in patients with chronic myeloid leukemia (CML). The authors concluded that the addition of pioglitazone improved response. Some background Chronic myeloid leukemia is a cancer of the bone marrow, where there is an excess of...
Read MoreIn a nutshell This study compared first-line treatment options for multiple myeloma with and without maintenance therapy. Researchers reported superior treatment outcomes with high-dose melphalan (Alkeran) plus stem cell transplantation when compared to a combination of orally administered treatments. Additional maintenance therapy with lenalidomide...
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