In a nutshell This study looked at how effective erythropoietin mouthwash was at preventing oral mucositis in cancer patients being treated with autologous stem cell transplantation. The study concluded that rinsing with erythropoietin mouthwash can prevent oral mucositis. Some background Oral mucositis (OM) is a complication associated with...
Read MoreIn a nutshell This study examined predictors of outcomes with stem cell transplantation from a donor (allo-SCT) for chronic lymphocytic leukemia (CLL). Researchers reported good long-term outcomes for young high-risk CLL patients treated with allo-SCT. Patients with matched sibling donors showed better outcomes compared to those with matched unrelated...
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In a nutshell This study examined treatment combinations involving imatinib (Gleevec) for chronic myeloid leukemia (CML). Researchers concluded that treatment with standard-dose imatinib achieved a survival comparable to that of the general population. Patient disease factors affected outcomes more than initial treatment selection. Some background...
Read MoreIn a nutshell This study reviewed evidence on the management of high-risk multiple myeloma. Some background Multiple myeloma is a diverse disease. Using predictors of treatment success is important to help select treatment approaches for patients. Higher risk patients may benefit from more aggressive treatment. There are multiple methods...
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In a nutshell This study compared rituximab and GP2013 treatments in patients with previously untreated advanced stage follicular lymphoma. The study concluded that patients treated with GP2013 had similar outcomes to patients treated with rituximab. Some background Follicular lymphoma (FL) is a type of non-Hodgkin lymphoma. It is commonly...
Read MoreIn a nutshell This study analyzed outcomes in advanced skin cancer patients who stopped their treatment of nivolumab (Opdivo) and ipilimumab (Yervoy) due to side effects. This study concluded that many patients still benefit from the combination even after stopping treatment. Some background...
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In a nutshell This study looked survival rates of stage II rectal cancer patients who underwent different treatments. It compared radical surgery versus local excision with added-on chemoradiation. The article concluded that overall survival was not different between the treatments. Some background Radical surgery (RS – complete...
Read MoreIn a nutshell This study looked at the effect of chemoradiation (CRT) and local surgical treatment (local excision – LE) on quality of life in patients with stage II rectal cancer. It found that this treatment had little effect on lower bowel function (anorectum) and quality of life. Some background...
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In a nutshell This phase 2 clinical trial will test the safety and effectiveness of durvalumab as a first-line therapy for non-small cell lung cancer (NSCLC). The primary outcome will be measured by overall survival and the number of patients with adverse (negative) side effects. The details Durvalumab is an immunotherapy for metastatic tumors...
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In a nutshell This phase 2 trial will clinical trial will test the effectiveness of lorlatinib in treating non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) and ROS proto-oncogene 1 (ROS1) mutations. The primary outcome will be measured by the rate at which the disease spreads to the central nervous system (CNS). The...
Read MoreIn a nutshell This phase 2 clinical trial will test the effectiveness of isatuximab (SAR650984) in patients with high-risk smoldering multiple myeloma. The primary outcome will be measured by the overall response. This trial is being conducted at Mount Sinai Hospital and Memorial Sloan Kettering Cancer Center in New York, New York, as well as...
Read MoreIn a nutshell This meta-analysis aimed to establish the incidence of severe and fatal side effects associated with crizotinib (Xalkori) in patients with ALK-positive non-small-cell lung cancer (NSCLC). The authors concluded that crizotinib does not increase the risk of severe or fatal side effects compared to chemotherapy. Some background The...
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