In a nutshell This study looked at the effectiveness of autologous stem cell transplantation after their first remission for patients with high-risk diffuse large B-cell lymphoma. The study concluded that patients who received autologous stem cell transplantation had better outcomes than those who did not. Some background Diffuse large B-cell...
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In a nutshell This study investigated the impact monitoring an early stage prostate cancer had on quality of life or psychological state of mind. The study found that active surveillance or watchful waiting, instead of active treatment, has a minor impact on psychological and quality of life outcomes in the long-term. Some background Active...
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In a nutshell This study examined 3 different azacitidine-based (Vidaza) treatment approaches for patients with chronic myelomonocytic leukemia (CMML). Researchers reported that patients with CMML showed better treatment response when azacitidine was combined with lenalidomide (Revlimid). Some background Myelodysplastic syndromes (MDS) are a group...
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In a nutshell This phase 2 trial aims to test the effectiveness of the combined treatment of three different immunotherapies. The main outcomes of this trial will be the tumor response to the treatment and the overall survival. The details Immunotherapies stimulate the immune system to attack and kill cancer cells the way it would a virus or...
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In a nutshell This study compared the effectiveness and safety of laparoscopy (LRS) and robotic rectal cancer surgery (RRS). Researchers suggested that both treatments have similar cancer outcomes and side effects. Some background LRS (removal of the tumor by using a cable with a camera inserted near the tumor) is a non-invasive option...
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In a nutshell This paper studied the effectiveness of bortezomib (Velcade), cyclophosphamide (Cytoxan) and dexamethasone in patients with multiple myeloma who had not been previously treated. The combination of bortezomib, cyclophosphamide and dexamethasone was found to be effective and well-tolerated. Some background Multiple myeloma is a...
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In a nutshell This study reviewed evidence of novel agents in the treatment of chronic myeloid leukemia (CML). Some background CML is a disease in which the bone marrow makes too many mature and immature white blood cells. It is typically a slowly progressing disease that occurs mainly during or after middle age. Most patients are diagnosed in the...
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In a nutshell This study looked at how well thymus and activation-regulated chemokine (TARC) levels can predict outcomes for patients with Hodgkin lymphoma. The authors concluded that an early reduction in TARC levels can predict that treatment will be successful. Some background Hodgkin lymphoma (HL) is generally considered a curable...
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In a nutshell This study examined the effectiveness of FOLFOXIRI combined with targeted therapy (TT) in advanced colorectal cancer. This study concluded that FOLFOXIRI plus TT was associated with better outcomes compared to other treatment combinations. Some background Chemotherapy is used to reduce symptoms and increase survival in colorectal...
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In a nutshell This study looked at how effective the combination of bendamustine plus rituximab was at treating patients with indolent B-cell non-Hodgkin lymphoma (B-NHL) and mantle cell lymphoma (MCL). The study concluded that bendamustine plus rituximab is safe and effective for treating patients with indolent B-NHL and MCL. Some...
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In a nutshell This study compared the effectiveness of two types of tyrosine kinase inhibitors – imatinib (Gleevac) and radotinib (Supect) – for chronic myeloid leukemia (CML). Researchers concluded that response to treatment occurred sooner and more strongly with radotinib than with imatinib. Some background Tyrosine kinase...
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In a nutshell This study analyzed the results of 13 separate studies on treatment combinations for multiple myeloma patients with the 17p deletion. This study concluded that bortezomib-based primary and maintenance therapy improved outcomes in newly diagnosed patients with the 17p deletion. The combination...
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