In a nutshell This trial is investigating the effectiveness of pembrolizumab (Keytruda) plus enzalutamide (Xtandi) in patients with prostate cancer. The primary outcome to be measured will be the absence of cancer on the prostate after it is surgically removed. This study is being conducted in Portland, OR. The details...
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Do side-effects vary between risk groups after treatment for localized prostate cancer?
In a nutshell This study aimed to determine whether differences in side effects reported over time in patients who had surgery or radiotherapy varied by risk group. This study found that for men with low-risk prostate cancer, radiotherapy was associated with higher sexual function scores at 3 years than surgery;...
Read MoreWhich type of prostate surgery is more effective at reducing biochemical recurrence?
In a nutshell The authors aimed to determine the benefit of robot-assisted radical prostatectomy (RARP) compared to retro-pubic radical prostatectomy (RRP) in reducing biochemical recurrence in men with prostate cancer. The authors concluded that RARP compared to RRP improved positive surgical margins (PSM) and biochemical recurrence. Some...
Read MoreSearching for men to test focal therapy for ablation of prostate cancer
In a nutshell This study aims to test the effectiveness of focal ablation (laser therapy used to remove and kill cancer cells) of large prostate cancer sites using ultrasound and biopsy (tissue samples taken from the cancer site) one year after treatment. The main outcome to be measured will be the removal of cancer cells confirmed by a negative biopsy...
Read MoreHormone therapy and the risk of heart problems in men with prostate cancer
In a nutshell The authors aimed to review the different types of hormone therapy and their effect on cardiovascular morbidity and death rates in men with prostate cancer. The authors concluded that it was difficult to determine which type of hormone therapy affected the risk for cardiovascular morbidity and that further detailed research was...
Read MoreCan sentinel lymph node dissection be used to identify patients who could benefit from further therapy?
In a nutshell The aim of the study was to examine if sentinel lymph node dissection (SLND) could be used to select patients with prostate cancer who would benefit from further pelvic radiation therapy and long-term androgen deprivation therapy (ADT). It was concluded that SLND could be used as a tool to determine whether patients should have more...
Read MoreComparing outcomes of radiation therapy and observation in patients over 80
In a nutshell This study examined different treatment options for elderly men with localized prostate cancer. Researchers reported that radiation therapy with or without hormone therapy was associated with a significant survival benefit when compared to observation alone. Some background Localized prostate cancer refers to cancer that is confined...
Read MoreComparing the benefits of different local therapies before hormone therapy
In a nutshell This study compared the benefit of combining different local therapies with hormone therapy for metastatic prostate cancer. Researchers reported a survival benefit for patients treated with surgery or intensity modulated radiation therapy (a type of radiation therapy) before hormone therapy. Some background Hormone therapy is...
Read MoreHormone therapy during or after radiation therapy increases the risk of cardiovascular events
In a nutshell This study examined the effect of androgen deprivation therapy (ADT) on the risk of cardiovascular events (such as stroke or heart attack) in men treated with radiation therapy. Researchers concluded that ADT use during or after radiation therapy increases the risk of cardiovascular events. Some background Radiation therapy is a...
Read MoreEarly use of chemotherapy in metastatic prostate cancer – an overview of current evidence
In a nutshell This study examined evidence for the benefits of adding chemotherapy early to hormone therapy for metastatic prostate cancer. Authors concluded that early evidence indicates a survival benefit with the addition of chemotherapy for metastatic prostate cancer. Some background Androgen deprivation therapy (ADT) is a type of hormone...
Read MoreSurvival benefits for men treated with local therapies before starting chemotherapy
In a nutshell This study examined the benefits of administering local therapies before chemotherapy for prostate cancer. Researchers reported lower mortality risks for men treated with local therapies before chemotherapy. Some background Local therapies, such as surgery or radiation, are first-line treatments for localized (confined) prostate...
Read MoreSearching for men with low- to intermediate-risk prostate cancer to test precise radiation therapy guided by an imaging technique
In a nutshell This trial aims to examine stereotactic radiosurgery guided by an imaging technique in treating low- to intermediate-risk prostate cancer. The main outcome to be investigated is treatment-related side effects and treatment response. The trial is recruiting in Ohio (USA). The details Stereotactic radiosurgery (SRS) uses a specially...
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