In a nutshell The authors analyzed the safety and effectiveness of certolizumab pegol (Cimzia) in combination with methotrexate (Trexall) in the treatment of rheumatoid arthritis (RA). Some background In RA, high levels of immune system proteins are generated. This causes inflammation, leading to chronic...
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In a nutshell The authors analyzed the occurrence of treatment-related side effects in rheumatoid arthritis (RA) and the factors that cause discontinuation of such treatments. Some background In RA, high levels of immune system proteins are generated. This causes inflammation, leading to chronic pain. Disease-modifying...
Read MoreIn a nutshell The authors analyzed the effect of dose reduction in rheumatoid arthritis patients (RA) in remission (disease recovery). Some background Disease-modifying antirheumatic drugs (DMARDs) are safe and effective treatments in patients with RA. DMARDs can be chemical or biological. The objective of these treatments is to achieve...
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In a nutshell The authors compared the safety and long-term effectiveness of subcutaneous (injected under skin) tocilizumab (Actemra) to intravenous (injected through veins) tocilizumab in patients with rheumatoid arthritis (RA). Some background In RA, the body's immune system mistakenly attacks the...
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In a nutshell This study examined whether the disease activity of rheumatoid arthritis and its treatment can influence patient survival. Some background Rheumatoid arthritis (RA) is characterized by inflammation of the joints. The severity of RA varies among patients. Some patients may have mild disease activity, with only a few affected joints....
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In a nutshell This study examined whether rheumatoid arthritis patients with persistent moderate disease activity have a worse outcome than patients that achieve remission. Some background The severity of rheumatoid arthritis (RA) varies between patients. Treatments are given early after diagnosis in order to stop or reduce joint damage. Some...
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In a nutshell This study assessed the long-term safety and efficacy of abatacept (Orencia) plus methotrexate (Rheumatrex, Trexall) in patients with rheumatoid arthritis who have not responsed to methotrexate alone. Some background Rheumatoid arthritis is a chronic (long-term) disease that leads to inflammation of the joints. Methotrexate is one of...
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In a nutshell This study investigated whether a new vaccination for rheumatoid arthritis could improve patients' symptoms. Some background Vaccinations are generally used to prepare peoples’ immune system to fight a bacteria or a virus they might one day come in contact with, like measles or the flu. It is now possible that a...
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In a nutshell This study investigated how safe and successful golimumab is as an add-on therapy to a range of existing rheumatoid arthritis drugs. Some background Rheumatoid arthritis treatments aim to achieve and maintain remission (a decrease in or disappearance of signs and symptoms of disease). This in turn...
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In a nutshell This study compared methotrexate (Rheumatrex, Trexall) and tofacitinib (Xeljanz, Jakvinus) in patients suffering from rheumatoid arthritis (RA). Some background Methotrexate is currently the preferred initial treatment for patients with RA. However, some concern exists around the...
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In a nutshell This paper studied the effectiveness of Leining in treatment of patients with rheumatoid arthritis. Some background Methotrexate (Trexall, Rheumatrex) is used to treat rheumatoid arthritis. However, not all patients have an optimal response to methotrexate. Abatacept (Orencia) is an effective and...
Read MoreIn a nutshell This paper evaluates the effect of tocilizumab (Actemra) compared with other biologic therapies in improving anemia in rheumatoid arthritis patients. Some background Anemia (low number of red blood cells and hemoglobin, the oxygen-carrying component of blood) is a complication in rheumatoid...
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