In a nutshell This study looked at the effect of rituximab (Rituxan) and levels of immune cells in patients with rheumatoid arthritis (RA).The authors concluded that certain immune cells are linked to disease activity in patients treated with rituximab. Measuring the levels of these cells could be used to determine if rituximab re-treatment is...
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In a nutshell This study assessed joint symptoms and quality of life two years after total knee replacement surgery in patients with rheumatoid arthritis. The study concluded that rheumatoid arthritis patients undergoing knee replacement surgery experience good outcomes. Some background Total knee replacement surgery is a common treatment for...
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In a nutshell This study examined whether golimumab (Simponi) is safe and effective in rheumatoid arthritis patients who have previously used anti-tumor necrosis factor therapy. Some background Anti-tumor necrosis factor (TNF) therapy (Humira, Enbrel, Remicade and Cimzia) is used to treat patients who have a severe form of rheumatoid arthritis...
Read MoreIn a nutshell This study examined the frequency of gastrointestinal (digestive tract) events in at-risk rheumatic patients using non-steroidal anti-inflammatory drugs. Some background Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil) are used to relieve pain in patients with rheumatic diseases. However, they can also cause...
Read MoreIn a nutshell This study examined whether a combination of clinical and ultrasound assessments could identify rheumatoid arthritis patients suitable for a lower dose of anti-TNF alpha therapy. Some background Anti-TNF alpha therapy (Humira, Enbrel, Remicade and Cimzia) is used to treat patients who have a severe form of rheumatoid...
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In a nutshell This study investigated whether doctors could predict the long term effectiveness of infliximab (Remicade) treatment for rheumatoid arthritis, based on early results at 3 months. Some background Rheumatoid arthritis is an autoimmune disease, caused by the immune system attacking healthy tissue. Blocking the immune system...
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In a nutshell This study investigated whether MRP8/14 protein levels can predict rheumatoid arthritis patient response to biologic drug treatment. Some background Rheumatoid arthritis is an inflammatory disease affecting the joints, the connections between bones. The goal of drug therapy is remission: a time when the disease is not active and...
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